Family history as a risk factor for primary cardiac arrest
Family history as a risk factor for primary cardiac arrest
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DOI：
10.1161/01.cir.97.2.155
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发表时间：
1998-01-20
期刊：
影响因子：
37.8
通讯作者：
Cobb, LA
中科院分区：
文献类型：
--
作者：
Friedlander, Y;Siscovick, DS;Cobb, LA
背景--在一项基于人群的病例对照研究中，假设有心肌梗死(MI)或原发性心脏骤停(PCA)家族史是导致原发性心脏骤停的独立危险因素。此外，我们还调查了这些心血管事件的家族聚集性是否与公认的危险因素有关。方法和结果：通过随机数字拨号从社区中识别出25-74岁的PCa病例和年龄和性别匹配的人群对照对象。所有受试者都没有公认的临床心脏病和主要合并症。一级亲属的MI和PCA的详细历史是由训练有素的面试者使用标准化问卷在与病例和对照受试者的配偶的访谈中收集的。对于每个家族关系，病例亲属的MI或原发心脏骤停(MI/PCA)的发生率高于对照受试者的亲属。总体而言，心脏骤停患者一级亲属的MI/PCA比率比对照组一级亲属的MI/PCA比率高近50%(比率比[RR]=1.46；95%CI=1.23至1.72)。在多因素Logistic模型中，即使在调整了其他常见危险因素后，MI/PCa家族史仍与PCa相关(RR=1.57，95%CI=1.27~1.95)。结论：MI或Pca家族史与心脏骤停风险呈正相关。这种关联在很大程度上独立于其他常见危险因素的家族聚集。
Background-The hypothesis that a family history of myocardial infarction (MI) or primary cardiac arrest (PCA) is an independent risk factor for primary cardiac arrest was examined in a population-based case-control study. In addition, we investigated whether recognized risk factors account for the familial aggregation of these cardiovascular events.Methods and Results-PCA cases, 25 to 74 years old, attended by paramedics during the period 1988 to 1994 and population-based control subjects matched for age and sex were identified from the community by random digit dialing. All subjects were free of recognized clinical heart disease and major comorbidity. A detailed history of MI and PCA in first-degree relatives was collected in interviews with the spouses of case and control subjects by trained interviewers using a standardized questionnaire. For each familial relationship, there was a higher rate of MI or primary cardiac arrest (MI/PCA) in relatives of case compared with relatives of control subjects. Overall, the rate of MI/PCA among first-degree relatives of cardiac arrest patients was almost 50% higher than that in first-degree relatives of control subjects (rate ratio [RR]=1.46; 95% CI=1.23 to 1.72). In a multivariate logistic model, family history of MI/PCA was associated with PCA (RR=1.57, 95% CI=1.27 to 1.95) even after adjustment for other common risk factors.Conclusions-Family history of MI or PCA is positively associated with the risk of primary cardiac arrest. This association is mostly independent of familial aggregation of other common risk factors.