Low serotonin and dopamine metabolite concentrations in cerebrospinal fluid from bulimic patients with frequent binge episodes.
Low serotonin and dopamine metabolite concentrations in cerebrospinal fluid from bulimic patients with frequent binge episodes.
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频繁暴饮暴食的暴食症患者脑脊液中血清素和多巴胺代谢物浓度较低。
DOI：
10.1001/archpsyc.1992.01820020052007
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发表时间：
1992
影响因子：
--
通讯作者：
T. Brewerton
中科院分区：
文献类型：
--
作者：
D. Jimerson;M. Lesem;W. H. Kaye;T. Brewerton
研究脑脊液神经递质代谢物水平，以评估中枢血清素、多巴胺或去甲肾上腺素功能的测量是否与神经性贪食症患者异常饮食模式的严重程度相关。与健康对照者 (N = 17) 相比，每天暴食两次以上的住院贪食症患者 (N = 11) 的脑脊液中 5-羟基吲哚乙酸和高香草酸浓度显着降低。对于整个患者组（N = 29），两种代谢物的水平与暴饮暴食频率显着负相关。在临床前研究的基础上，在推测模型的背景下对这些结果进行了检验，其中中枢血清素功能低可能导致暴食症患者的饱腹感反应减弱，而中枢多巴胺活性低可能在对食物的异常享乐反应中发挥作用。
Cerebrospinal fluid neurotransmitter metabolite levels were studied to assess whether measures of central serotonin, dopamine, or norepinephrine function are associated with severity of abnormal eating patterns in patients with bulimia nervosa. In comparison with healthy controls (N = 17), hospitalized bulimic patients with a history of binge eating more frequently than twice daily (N = 11) had significantly lower CSF concentrations of 5-hydroxyindoleacetic acid and homovanillic acid. For the total patient group (N = 29), levels of both metabolites were significantly inversely correlated with binge frequency. On the basis of preclinical studies, these results were examined in the context of speculative models in which low central serotonin function might contribute to blunted satiety responses in bulimic patients, while low central dopamine activity might play a role in abnormal hedonic responses to food.
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DOI：
--
发表时间：
1990
期刊：
The Journal of pharmacology and experimental therapeutics
影响因子：
--
作者：
Kelland,MD;Freeman,AS;Chiodo,LA
通讯作者：
Chiodo,LA
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影响因子：
4.6
作者：
Rodin,J;Bartoshuk,L;Peterson,C;Schank,D
通讯作者：
Schank,D
暴食症门诊患者情感和其他精神疾病终生患病率的对照研究。
DOI：
10.1176/ajp.144.10.1283
发表时间：
1987
期刊：
The American journal of psychiatry
影响因子：
--
作者：
Hudson,JI;PopeJr,HG;Yurgelun-Todd,D;Jonas,JM;Frankenburg,FR
通讯作者：
Frankenburg,FR
影响因子：
--
作者：
Walsh,BT;Stewart,JW;Roose,SP;Gladis,M;Glassman,AH
通讯作者：
Glassman,AH