Status epilepticus-related etiology, incidence and mortality: A meta-analysis
Status epilepticus-related etiology, incidence and mortality: A meta-analysis
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DOI：
10.1016/j.eplepsyres.2017.07.006
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发表时间：
2017-10-01
影响因子：
2.2
通讯作者：
Shao, Xiao-Qiu
中科院分区：
文献类型：
--
作者：
Lv, Rui-Juan;Wang, Qun;Shao, Xiao-Qiu
癫痫持续状态 (SE) 是一种严重的疾病。为了确定 SE 的流行病学和结果，我们进行了一项荟萃分析来调查 SE 的病因、发病率和死亡率。我们检索了2000年1月1日至2016年10月31日期间的PubMed和Embase，不受地区限制，寻找SE病因、发病率和死亡率的观察性研究。荟萃分析中纳入了 43 项研究。 SE的汇总粗年发病率、汇总病死率和汇总粗年死亡率分别为12.6/100,000（95% CI：10.0-15.3）、14.9%（95% CI：11.7-118.7）和0.98/100,000（95% CI：0.74-1.22）。患有 SE 的老年受试者的病死率 (28.4% (95% CI: 17.7-42.3)) 和粗年发病率 (27.1% (95% CI: 15.8-38.2)) 较高。 SE 患者最重要的病因特异性归因部分是急性症状病因（OR 0.411，95% CI：0.315-0.507）。年龄和经济收入导致SE发病率和短期病死率的差异。
Status epilepticus (SE) is a severe medical condition. To determine its epidemiology and outcome of SE, we performed a meta-analysis to investigate the etiology, incidence and mortality of SE. We searched PubMed and Embase between Jan 1, 2000, and Oct 31, 2016, with no regional restrictions, for observational studies of the etiology, incidence and mortality of SE. Forty-three studies were included in the meta-analysis. The pooled crude annual incidence rate, the pooled case fatality rate and the pooled crude annual mortality rate of SE were 12.6/100,000 (95% CI: 10.0-15.3), 14.9% (95% CI: 11.7-118.7) and 0.98/100,000 (95% CI: 0.74-1.22), respectively. Elderly subjects with SE had a higher case fatality rate (28.4% (95% CI: 17.7-42.3)) and crude annual incidence rate (27.1% (95% CI: 15.8-38.2)). The most important etiology-specific attributable fraction of patients with SE was acute symptomatic etiology (OR 0.411, 95% CI: 0.315-0.507). Age and economic income contributed to differences in SE incidence and short-term case fatality rate.