Contraceptive testing of vaginal agents in rabbits
Contraceptive testing of vaginal agents in rabbits
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DOI：
10.1016/s0010-7824(98)00059-6
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发表时间：
1998-07-01
期刊：
影响因子：
2.9
通讯作者：
Cone, RA
中科院分区：
文献类型：
--
作者：
Castle, PE;Hoen, TE;Cone, RA
开发新的阴道产品，如杀微生物剂和避孕药，需要在体内测试其对生育力的影响。与在子宫内授精的较小的实验室动物如大鼠和小鼠不同，兔在阴道内授精，因此作为测试阴道药物避孕效果的动物模型是有价值的。与非人类灵长类动物相比，兔子价格便宜且易于操作，并且经常用于测试阴道制剂对生育力的影响。我们回顾了相关的文献和报告结果，为有效地使用和改进兔子避孕模型测试新的阴道产品提供指导。(C)1998年爱思唯尔科学公司All rights reserved.
Development of new vaginal products, such as microbiocides and contraceptives, requires in vivo testing of their effect on fertility. Rabbits, unlike smaller laboratory animals such as rats and mice, which inseminate in the uterus, inseminate vaginally and thus are valuable as animal models for testing vaginal agents for contraceptive effects. Rabbits are inexpensive and easy to handle compared to nonhuman primates, and have frequently been used for testing the effects of vaginal agents on fertility. We review the pertinent literature and report findings that provide guidance for effectively using and improving the rabbit contraceptive model in testing new vaginal products. (C) 1998 Elsevier Science Inc. All rights reserved.