Flavipesines A and B and Asperchalasines E-H: Cytochalasans and Merocytochalasans from Aspergillus flavipes
Flavipesines A and B and Asperchalasines E-H: Cytochalasans and Merocytochalasans from Aspergillus flavipes
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Flavipesines A 和 B 以及 Asperchalasines E-H：来自黄曲霉的细胞松弛素和粒细胞松弛素
DOI：
10.1021/acs.jnatprod.9b00512
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发表时间：
2019-11-01
影响因子：
5.1
通讯作者：
Zhang, Yonghui
中科院分区：
文献类型：
--
作者：
Zhang, Xiaotian;Yang, Lu;Zhang, Yonghui
从黄足曲霉中分离出黄脂素A和B（1和2）和曲霉松弛素E-H（3-6），这两种细胞松弛素具有一个不寻常的环系统，四种部分细胞松弛素具有一个5/6/11/5/5/6环系统，沿着还有三个相关化合物（7-9）。它们的结构，包括绝对构型，确定的基础上的数据从HRESIMS，NMR，ECD，分子建模，和单晶X-射线衍射。黄脂素A和B（1和2）代表具有5/6/7/6环系统和C-18-O-C-21桥的细胞松弛素的第一个例子。化合物3、7和9对异柠檬酸脱氢酶1（IDH 1）显示中等抑制活性。这是首次报道细胞松弛素的IDH 1抑制活性。
Flavipesines A and B (1 and 2) and asperchalasines E-H (3-6), two cytochalasans with an unusual ring system and four merocytochalasans possessing a 5/6/11/5/5/6 ring system, were isolated from Aspergillus flavipes, along with three related compounds (7-9). Their structures, including absolute configurations, were determined on the basis of data from HRESIMS, NMR, ECD, molecular modeling, and single-crystal X-ray diffraction. Flavipesines A and B (1 and 2) represent the first examples of cytochalasans possessing a 5/6/7/6 ring system with a C-18-O-C-21 bridge. Compounds 3, 7, and 9 show moderate inhibitory activities against isocitrate dehydrogenase 1 (IDH1). This is the first report on the IDH1 inhibitory activities of cytochalasans.