Lung and chest wall mechanics in rabbits during high-frequency body-surface oscillation.
Lung and chest wall mechanics in rabbits during high-frequency body-surface oscillation.
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高频体表振荡期间兔子的肺和胸壁力学。
DOI：
10.1152/jappl.1990.68.4.1722
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发表时间：
1990
期刊：
影响因子：
--
通讯作者：
Chang,HK
中科院分区：
文献类型：
--
作者：
Chartrand,DA;Maarek,JM;Ye,TH;Chang,HK
在8只麻醉和气管切开的家兔中，我们研究了正常碳酸通气时呼吸系统的传递阻抗，方法是高频体表振荡，频率从3到15 Hz。将总呼吸阻抗分为肺阻抗和胸壁阻抗，以表征每个组件的振荡机械特性。肺和胸壁阻力在3- 15 Hz范围内不依赖于频率。平均肺阻力为13.8 +/- 3.2（SD）cmH2O.l-1.s，尽管平均胸壁阻力为8.6 +/- 2.0 cmH2O.l-1.s。肺弹性和惯量分别为0.247 +/- 0.095 cmH_2O/ml和0.103 +/- 0.033 cmH_2O·l-1.s_2。胸壁弹性和惯性分别为0.533 ± 0.136 cmH_2O/ml和0.041 ± 0.063 cmH_2O·l-1.s_2。在线性机械行为下，使这些气管切开的动物恢复正常所需的经肺压力振荡在3 Hz时处于其最小值。当呼吸频率增加超过6-9 Hz时，维持正常碳酸血症所需的每分钟通气量和肺阻抗均增加。这些数据表明，在正常肺的兔子中，体表振荡通气更适合于相对中等的频率。
In eight anesthetized and tracheotomized rabbits, we studied the transfer impedances of the respiratory system during normocapnic ventilation by high-frequency body-surface oscillation from 3 to 15 Hz. The total respiratory impedance was partitioned into pulmonary and chest wall impedances to characterize the oscillatory mechanical properties of each component. The pulmonary and chest wall resistances were not frequency dependent in the 3- to 15-Hz range. The mean pulmonary resistance was 13.8 +/- 3.2 (SD) cmH2O.l-1.s, although the mean chest wall resistance was 8.6 +/- 2.0 cmH2O.l-1.s. The pulmonary elastance and inertance were 0.247 +/- 0.095 cmH2O/ml and 0.103 +/- 0.033 cmH2O.l-1.s2, respectively. The chest wall elastance and inertance were 0.533 +/- 0.136 cmH2O/ml and 0.041 +/- 0.063 cmH2O.l-1.s2, respectively. With a linear mechanical behavior, the transpulmonary pressure oscillations required to ventilate these tracheotomized animals were at their minimal value at 3 Hz. As the ventilatory frequency was increased beyond 6-9 Hz, both the minute ventilation necessary to maintain normocapnia and the pulmonary impedance increased. These data suggest that ventilation by body-surface oscillation is better suited for relatively moderate frequencies in rabbits with normal lungs.