Characterization of a novel respiratory syncytial virus-specific human cytotoxic T-lymphocyte epitope
Characterization of a novel respiratory syncytial virus-specific human cytotoxic T-lymphocyte epitope
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DOI：
10.1128/jvi.74.16.7694-7697.2000
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发表时间：
2000-08-01
影响因子：
5.4
通讯作者：
Walker, BD
中科院分区：
文献类型：
--
作者：
Goulder, PJR;Lechner, F;Walker, BD
呼吸道合胞病毒（RSV）感染是全球儿童发病的主要原因。描述了第一个待定义的人RSV特异性细胞毒性T淋巴细胞表位。使用B7-RSV-NP四聚体复合物染色CD 8 + T细胞，在4名健康的B7阳性成年受试者中可检测到核蛋白（NP）中的HLA B7限制性表位。
Respiratory syncytial virus (RSV) infection is a major cause of morbidity in childhood worldwide. The first human RSV-specific cytotoxic T-lymphocyte epitope to be defined is described. This HLA B7-restricted epitope in nucleoprotein (NP) was detectable in four healthy, B7-positive adult subjects using B7-RSV-NP tetrameric complexes to stain CD8+ T cells.