ACQUIRED RED-CELL PYRUVATE-KINASE DEFICIENCY IN LEUKEMIAS AND RELATED DISORDERS
ACQUIRED RED-CELL PYRUVATE-KINASE DEFICIENCY IN LEUKEMIAS AND RELATED DISORDERS
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DOI：
10.1159/000459004
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发表时间：
1975-01-01
期刊：
影响因子：
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通讯作者：
KAHN, A
中科院分区：
文献类型：
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作者：
BOIVIN, P;GALAND, C;KAHN, A
作者对202例不同类型h2013.2013.03病患者的红细胞丙酮酸激酶活性进行了研究。在39%的急性髓母细胞白血病患者、57%的原发性髓细胞功能不全无发育不全患者和61%的难治性铁母细胞贫血患者中发现中度PK缺乏。PK缺乏通常与其他红细胞酶的缺乏有关。这种酶异常的机制与翻译后分子改变的假设进行了讨论。
The authors studied red blood cell pyruvate kinase activity of 202 patients with various hémopathies. A PK deficiency of moderate grade was found in 39% of patients with acute myeloblastic leukemias, in 57% of those with primary medullary insufficiency without aplasia, in 61 % of those with refractory sideroblastic anemia. The PK deficiency was often associated with deficiencies of other red cell enzymes. The mechanism of such enzyme abnormalities was discussed with the hypothesis of a posttranslational molecular alteration.