MUC1 activates JNK1 and inhibits apoptosis under genotoxic stress
MUC1 activates JNK1 and inhibits apoptosis under genotoxic stress
复制标题
MUC1 激活 JNK1 并抑制基因毒性应激下的细胞凋亡
DOI：
10.1016/j.bbrc.2013.09.055
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发表时间：
2013-10-11
影响因子：
3.1
通讯作者：
Xiao, Zhi-Xiong
中科院分区：
文献类型：
--
作者：
Chen, Qiongqiong;Li, Decai;Xiao, Zhi-Xiong
The MUC1 transmembrane glycoprotein is aberrantly overexpressed in diverse human carcinomas and has been shown to inhibit apoptosis induced by genotoxic agents. In the present work, we report that MUC1 binds to and activates JNK1, an important member of the mitogen-activated protein kinases (MAPK) superfamily. The physical interaction between MUC1 cytoplasmic domain (MUC1-CD) and JNK1 was established by GST-pull-down assay in vitro and co-immunoprecipitation assay in vivo. We show that MUC1 activates JNK1 and inhibits cisplatin-induced apoptosis in human colon cancer HCT116 cells. Pharmacological inhibition of JNK or knockdown of JNK significantly reduces the ability of MUC1 to inhibit cisplatin-induced apoptosis. Together, our data indicate that MUC1 can inhibit apoptosis via activating JNK1 pathway in response to genotoxic anticancer agents. (C) 2013 Elsevier Inc. All rights reserved.
