LABIAL SALIVARY-GLAND BIOPSY IN SJOGRENS SYNDROME - ASSESSMENT AS A DIAGNOSTIC CRITERION IN 362 SUSPECTED CASES
LABIAL SALIVARY-GLAND BIOPSY IN SJOGRENS SYNDROME - ASSESSMENT AS A DIAGNOSTIC CRITERION IN 362 SUSPECTED CASES
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DOI：
10.1002/art.1780270205
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发表时间：
1984-01-01
影响因子：
--
通讯作者：
DANIELS, TE
中科院分区：
文献类型：
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作者：
DANIELS, TE
口干症是干燥综合征（SS）唾液成分的一个不令人满意的诊断标准。为了确定唇唾液腺（LSG）活检标本中存在局灶性涎腺炎的诊断有用性，362例疑似SS的患者前瞻性地接受了独特的LSG活检程序。将LSG炎症的模式和严重程度与腮腺流速的测量值以及是否存在症状性口干症、大唾液腺肿大、干燥性角结膜炎（KCS）和其他结缔组织疾病（CTD）进行比较。LSG活检病灶评分> 1与单独KCS和KCS + CTD的诊断比腮腺流速降低或口干症状更密切相关（分别为P < 0.0005和P < 0.05）。在足够的LSG标本中出现局灶性涎腺炎是一个客观标准，并且比口干症或任何其他唾液腺疾病的特征更具疾病特异性。SS的唾液成分应重新定义为存在LSG局灶性涎腺炎。
Xerostomia is an unsatisfactory diagnostic criterion for the salivary component of Sjogren''s syndrome (SS). To determine the diagnostic usefulness of the presence of focal sialadenitis in labial salivary gland (LSG) biopsy specimens, 362 patients suspected of having SS prospectively underwent a unique LSG biopsy procedure. The pattern and severity of LSG inflammation were compared with measurements of parotid flow rate, and the presence or absence of symptomatic xerostomia, major salivary gland enlargement, keratoconjunctivitis sicca (KCS) and other connective tissue diseases (CTD). LSG biopsy focus scores of > 1 correlated more closely with the diagnoses of KCS alone and with KCS plus a CTD than did either reduced parotid flow rate or symptoms of xerostomia (P < 0.0005 and P < 0.05, respectively). Focal sialadenitis in an adequate LSG specimen is an objective criterion and a more disease-specific feature of SS than xerostomia or any other feature of salivary disease. The salivary component of SS should be redefined as the presence of LSG focal sialadenitis.