Physical activity levels before and after a diagnosis of breast carcinoma - The health, eating, activity, and lifestyle (HEAL) study
Physical activity levels before and after a diagnosis of breast carcinoma - The health, eating, activity, and lifestyle (HEAL) study
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DOI：
10.1002/cncr.11227
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发表时间：
2003-04-01
期刊：
影响因子：
6.2
通讯作者：
Ballard-Barbash, R
中科院分区：
文献类型：
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作者：
Irwin, ML;Crumley, D;Ballard-Barbash, R
背景在患者被诊断患有乳腺癌时体重增加与复发风险增加和存活率降低相关。诊断后体重增加也很常见。诊断后增加体力活动（PA）可以最大限度地减少这些不良后果。在这项基于人群的研究中，作者调查了812例乳腺癌患者（从原位到IIIa期）诊断后PA水平是否从诊断前水平下降，以及PA的任何变化是否因疾病分期、辅助治疗、患者年龄或体重指数（BMI）而异。诊断前一年和面谈前一个月的体育和家庭活动类型及其频率和持续时间（即，4-12诊断后3个月）在基线访谈期间进行评估。从诊断前到诊断后，患者的总PA每周减少约2.0小时，减少11%（P < 0.05）。在接受放疗和化疗的女性中观察到运动PA的下降幅度更大（下降50%），与仅接受手术（下降24%）或仅接受放疗（23%）的女性相比（P < 0.05）。肥胖患者运动性PA下降幅度（41%）大于正常体重患者（24%）（P < 0.05）。乳腺癌患者PA水平明显降低。在体重较重的患者中观察到的PA下降幅度较大，这意味着已经超重的女性体重增加的可能性更大。需要随机对照试验来评估PA如何改善乳腺癌患者的预后。(C)美国癌症协会
BACKGROUND. increased body weight at the time patients are diagnosed with breast carcinoma has been associated with an increased risk of recurrence and reduced survival. Weight gain also is common after diagnosis. Increasing physical activity (PA) after diagnosis may minimize these adverse outcomes. In this population-based study, the authors investigated whether PA levels after diagnosis declined from prediagnosis levels and whether any changes in PA varied by disease stage, adjuvant treatment, patient age, or body mass index (BMI) in 812 patients with incident breast carcinoma (from in situ to Stage IIIa).METHODS. Types of sports and household activities and their frequency and duration for the year prior to diagnosis and for the month prior to the interview (i.e., 4-12 months postdiagnosis) were assessed during a baseline interview.RESULTS. Patients decreased their total PA by an estimated 2.0 hours per week from prediagnosis to postdiagnosis, an 11% decrease (P < 0.05). Greater decreases in sports PA were observed among women who were treated with radiation and chemotherapy (50% decrease) compared with women who underwent surgery only (24% decrease) or who were treated with radiation only (23%; (P < 0.05). Greater decreases in sports PA were observed among obese patients (41% decrease) compared with patients of normal weight (24% decrease; P < 0.05).CONCLUSIONS. PA levels were reduced significantly after patients were diagnosed with breast carcinoma. Greater decreases in PA observed among heavier patients implied a potential for greater weight gain among women who already were overweight. Randomized, controlled trials are needed to evaluate how PA may improve the prognosis for patients with breast carcinoma.(C) American Cancer Society