Relation of titred peripheral pattern ANA to anti-DNA and disease activity in systemic lupus erythematosus.
Relation of titred peripheral pattern ANA to anti-DNA and disease activity in systemic lupus erythematosus.
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滴定外周模式 ANA 与系统性红斑狼疮抗 DNA 和疾病活动的关系。
DOI：
10.1136/ard.36.1.44
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发表时间：
1977
影响因子：
27.4
通讯作者：
S. Walker
中科院分区：
文献类型：
--
作者：
R. J. Weitzman;S. Walker
本研究比较了免疫荧光抗核抗体（ANA）检测与改良法尔技术测量的抗DNA检测的外周模式的临床实用性。对48例活动期或非活动期系统性红斑狼疮（SLE）患者进行了研究。血清滴度与外周ANA模式（TP-ANA）和抗DNA值之间无相关性。Tp-ANA与SLE活动性无相关性。与此相反，抗DNA与肾脏疾病的严重程度，血清补体降低，SLE标准的数量。在另一组9例SLE患者中，随着疾病活动的控制，tp-ANA和抗DNA下降。然而，这两个参数是相互独立的。结论：tp-ANA不能准确反映SLE患者的抗DNA抗体或活动性。
This study compared the clinical usefulness of the peripheral pattern detected in immunofluorescent antinuclear antibody (ANA) testing with anti-DNA measured by the modified Farr technique. 48 patients with active or inactive systemic lupus erythematosus (SLE) were studied at one point in the course of their disease. There was no association between titres of serum giving a peripheral ANA pattern (tp-ANA) and anti-DNA values. Tp-ANA did not correlate with activity of SLE. In contrast with this finding, anti-DNA correlated with severity of renal disease, decreased serum complement, and number of SLE criteria. In a separate group of 9 patients with flare-ups of SLE, tp-ANA and anti-DNA fell as disease activity was controlled. Nevertheless, these two parameters were independent of one another. It was concluded that tp-ANA did not accurately reflect anti-DNA or activity of SLE.