Enhanced cortisol suppression following dexamethasone administration in domestic violence survivors
Enhanced cortisol suppression following dexamethasone administration in domestic violence survivors
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DOI：
10.1176/appi.ajp.162.6.1192
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发表时间：
2005-06-01
影响因子：
17.7
通讯作者：
Yehuda, R
中科院分区：
文献类型：
--
作者：
Griffin, MG;Resick, PA;Yehuda, R
目的：作者比较了女性家庭暴力幸存者和一组匹配的非创伤参与者的反应，低剂量（0.5毫克）地塞米松抑制试验（DST）。方法：招募了70名女性家庭暴力幸存者和14名年龄和种族匹配的非创伤妇女。参与者评估创伤严重程度，PTSD和抑郁症状的严重程度，以及DST皮质醇反应。在符合DST标准的家庭暴力幸存者中，将患有PTSD（N=15）、PTSD+抑郁症（N=27）、无PTSD或抑郁症诊断（N=8）的人与非创伤对照受试者（N=14）进行比较，沿着。患有PTSD的家庭暴力幸存者，无论他们是否患有抑郁症，在9：00 a. M.健康受试者和没有诊断的创伤幸存者。唯一诊断为PTSD的幸存者表现出显着更大的皮质醇抑制地塞米松比健康受试者或组诊断为PTSD加depression.Conclusions：这些研究结果与以往的研究表明下丘脑-垂体-肾上腺（HPA）轴异常PTSD。研究结果表明，家庭暴力的慢性性质导致HPA轴的严重失调。
Objective: The authors compared responses of female domestic violence survivors and a matched group of nontraumatized participants to a low-dose (0.5 mg) dexamethasone suppression test (DST).Method: Seventy female domestic violence survivors and 14 nontraumatized women matched for age and race were recruited. Participants were assessed for trauma severity, severity of PTSD and depressive symptoms, and DST cortisol response. Of the domestic violence survivors who were DST-compliant, comparisons were made among those with PTSD (N=15), those with PTSD plus depression (N=27), and those with no PTSD or depression diagnosis (N=8) along with the nontraumatized comparison subjects (N=14).Results: Domestic violence survivors with PTSD, regardless of whether or not they had comorbid depression, had significantly lower baseline cortisol levels at 9: 00 a. m. than the healthy subjects and trauma survivors with no diagnosis. Survivors with a sole diagnosis of PTSD showed significantly greater cortisol suppression to dexamethasone than did healthy subjects or the group diagnosed with PTSD plus depression.Conclusions: These findings agree with previous studies showing hypothalamic-pituitary-adrenal (HPA) axis abnormalities in PTSD. The findings suggest that the chronic nature of domestic violence leads to a severe dysregulation of the HPA axis.