Antimicrobial peptides from fish.
Antimicrobial peptides from fish.
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DOI：
10.3390/ph7030265
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发表时间：
2014-03-03
期刊：
影响因子：
--
通讯作者：
Diamond G
中科院分区：
文献类型：
--
作者：
Masso-Silva JA;Diamond G
抗菌肽（Antimicrobial Peptides，AMP）广泛分布于自然界，参与各种生物的天然防御。鱼是这些肽的重要来源，因为它们表达所有主要类别的AMP，包括防御素、凯萨林菌素、铁调素、组蛋白衍生肽和称为鱼调素的鱼特异性天蚕素家族类别。与其他物种一样，鱼肽具有广谱抗菌活性，可杀死鱼类和人类病原体。它们也具有免疫调节作用，其基因对微生物和先天免疫刺激分子高度敏感。最近的研究表明，鱼肽的一些独特性质，包括它们即使在非常高的盐浓度下也能发挥作用的能力，使它们成为开发治疗性抗菌剂的良好潜在靶点。此外，通过外源因子刺激它们的基因表达可能有助于预防水产养殖中的病原微生物。
Antimicrobial peptides (AMPs) are found widely distributed through Nature, and participate in the innate host defense of each species. Fish are a great source of these peptides, as they express all of the major classes of AMPs, including defensins, cathelicidins, hepcidins, histone-derived peptides, and a fish-specific class of the cecropin family, called piscidins. As with other species, the fish peptides exhibit broad-spectrum antimicrobial activity, killing both fish and human pathogens. They are also immunomodulatory, and their genes are highly responsive to microbes and innate immuno-stimulatory molecules. Recent research has demonstrated that some of the unique properties of fish peptides, including their ability to act even in very high salt concentrations, make them good potential targets for development as therapeutic antimicrobials. Further, the stimulation of their gene expression by exogenous factors could be useful in preventing pathogenic microbes in aquaculture.