Period Responses to Zeitgeber Signals Stabilize Circadian Clocks During Entrainment
Period Responses to Zeitgeber Signals Stabilize Circadian Clocks During Entrainment
复制标题
对时间信号的周期响应可在夹带期间稳定昼夜节律时钟
DOI：
10.1081/cbi-120020422
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发表时间：
2003
影响因子：
2.8
通讯作者：
V. Sharma
中科院分区：
文献类型：
--
作者：
V. Sharma
具有特征周期（τ）的昼夜节律时钟可以借助于（i）由于D/L“黎明”和/或L/D“黄昏”转变引起的相移、（ii）与长期曝光相关联的周期变化、或（iii）通过上述可能性的组合而被带入亮/暗（LD）周期。基于模型生物钟的稳定性分析，预测夜间穴居哺乳动物将受益于周期反应比他们的昼夜同行。该模型进一步预测，当生物钟响应于光刺激而稍微改变其相位和周期时，生物钟达到最大稳定性。对部分昼行性和夜行性哺乳动物的经验相位响应曲线（PRC）和周期响应曲线（τRC）的分析表明，昼行性和夜行性哺乳动物的PRC具有相似的波形，而夜行性哺乳动物的τ RC比昼行性哺乳动物的振幅小。τRC的形状也随着年龄和光刺激强度的增加而变化。在不同天气条件下光强度的不稳定波动期间，生物钟夹带相位的稳定性似乎是通过相位和周期响应与光刺激强度之间的相互作用来实现的。
Circadian clocks with characteristic period (τ) can be entrained to light/dark (LD) cycles by means of (i) phase shifts which are due to D/L “dawn” and/or L/D “dusk” transitions, (ii) period changes associated with long-term light exposure, or (iii) by combinations of the above possibilities. Based on stability analysis of a model circadian clock it was predicted that nocturnal burrowing mammals would benefit less from period responses than their diurnal counterparts. The model further predicted that maximal stability of circadian clock is reached when the clock slightly changes both its phase and period in response to light stimuli. Analyses of empirical phase response curve (PRC) and period response curve (τRC) of some diurnal and nocturnal mammals revealed that PRCs of both diurnal and nocturnal mammals have similar waveform while τRCs of nocturnal mammals are of smaller amplitude than those of diurnal mammals. The shape of the τRC also changes with age and with increasing strength of light stimuli. During erratic fluctuations in light intensity under different weather conditions, the stability of phase of entrainment of circadian clocks appears to be achieved by an interplay between phase and period responses and the strength of light stimuli.
影响因子：
56.9
作者：
GINTY, DD;KORNHAUSER, JM;GREENBERG, ME
通讯作者：
GREENBERG, ME
影响因子：
56.9
作者：
DING, JM;CHEN, D;GILLETTE, MU
通讯作者：
GILLETTE, MU
DOI：
--
发表时间：
1999
期刊：
Recent progress in hormone research
影响因子：
--
作者：
M. Gillette;S. Tischkau
通讯作者：
M. Gillette;S. Tischkau