cDNA cloning of mouse VLA-3 alpha subunit.
cDNA cloning of mouse VLA-3 alpha subunit.
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小鼠 VLA-3 α 亚基的 cDNA 克隆。
DOI：
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发表时间：
1995
影响因子：
4
通讯作者：
T. Irimura
中科院分区：
文献类型：
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作者：
K. Takeuchi;K. Hirano;T. Tsuji;T. Osawa;T. Irimura
分离了小鼠甚晚抗原-3 α亚基（α 3整合素）的cDNA克隆并进行了测序。编码的小鼠α 3整合素亚基由1053个氨基酸残基组成。序列分析结果显示其他VLA α亚基具有相似的结构特征。例如，存在一个大的胞外结构域，包括三个假定的金属结合序列，一个跨膜结构域和一个短细胞质结构域。通过Northern blotting分析，胸腺比肾、胃、脾、肝、脑或肺中检测到更高水平的信息。
cDNA clones for mouse VLA (very late antigen)-3 alpha subunit (alpha 3 integrin) were isolated and sequenced. The encoded mouse alpha 3 integrin subunit was composed of 1,053 amino acid residues. The results of sequence analysis revealed similar structural characteristics of other VLA alpha subunits. For example, the presence of a large extracellular domain including three putative metal binding sequences, a transmembrane domain, and a short cytoplasmic domain. A higher level of its message was detected in thymus than in kidney, stomach, spleen, liver, brain, or lung by Northern blotting analysis.