Identification and Function of MicroRNAs Encoded by Herpesviruses.
Identification and Function of MicroRNAs Encoded by Herpesviruses.
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DOI：
10.1007/s12250-008-2997-9
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发表时间：
2008-12-01
影响因子：
5.5
通讯作者：
Gao, Shou-Jiang
中科院分区：
文献类型：
--
作者：
Bai, Zhi-Qiang;Lei, Xiu-Fen;Wang, Lin-Ding;Gao, Shou-Jiang
微小RNA（microRNAs，miRNAs）在真核生物、植物和一些病毒中发挥着重要作用。越来越清楚的是，由病毒编码的miRNA可以影响病毒的生命周期和宿主生理。病毒miRNAs可以抑制宿主的先天性和适应性免疫，调节细胞信号通路，调节细胞和病毒基因的表达。这些功能促进病毒急性和持续感染，并对宿主细胞存活和疾病进展具有深远影响。在这里，我们讨论了由疱疹病毒编码的miRNA，以及它们在病毒-宿主相互作用中的调节作用。
MicroRNAs (miRNAs) play important roles in eukaryotes, plants and some viruses. It is increasingly clear that miRNAs-encoded by viruses can affect the viral life cycle and host physiology. Viral miRNAs could repress the innate and adaptive host immunity, modulate cellular signaling pathways, and regulate the expression of cellular and viral genes. These functions facilitate viral acute and persistent infections, and have profound effects on the host cell survival and disease progression. Here, we discuss the miRNAs encoded by herpesviruses, and their regulatory roles involved in virus-host interactions.