SMALL-VOLUME AND LOW FLOW-RATE ELECTROSPRAY-IONIZATION MASS-SPECTROMETRY OF AQUEOUS SAMPLES
SMALL-VOLUME AND LOW FLOW-RATE ELECTROSPRAY-IONIZATION MASS-SPECTROMETRY OF AQUEOUS SAMPLES
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DOI：
10.1002/rcm.1290071111
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发表时间：
1993-11-01
影响因子：
2
通讯作者：
SMITH, RD
中科院分区：
文献类型：
--
作者：
GALE, DC;SMITH, RD
一种新的电喷雾电离源（发射器）已经开发出来，它可以以比之前演示的低得多的流速有效利用非常小的样品体积。小直径蚀刻尖端毛细管已合并到压力注入电喷雾电离源中。几种生物聚合物证明了在不使用辅助鞘流的情况下电喷雾水溶液的能力。与标准甲醇鞘源相比，该源观察到高信号强度和稳定的信号。
A new electrospray ionization source (emitter) has been developed which allows the effective utilization of very small sample volumes at much lower flow rates than previously demonstrated. A small diameter etched-tip capillary has been incorporated into a pressure-infusion electrospray ionization source. The ability to electrospray aqueous solutions without the use of an ancillary sheath flow is demonstrated with several biopolymers. High signal intensities and stable signals are observed for this source in a comparison with a standard methanol-sheath source.