Hippocampal volume in patients with alcohol dependence
Hippocampal volume in patients with alcohol dependence
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DOI：
10.1001/archpsyc.56.4.356
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发表时间：
1999-04-01
影响因子：
--
通讯作者：
Hommer, DW
中科院分区：
文献类型：
--
作者：
Agartz, I;Momenan, R;Hommer, DW
背景：据报道，与健康受试者相比，酗酒患者大脑中的海马体积更小，尽管尚不清楚海马是否不成比例地小于整个大脑。有证据表明，酗酒的女性比酗酒的男性更容易受到酒精对肝脏和心脏的损害。目前尚不清楚女性大脑的海马体是否更容易受到酒精的影响。方法：我们比较了52名住院的酗酒男女和36名健康的非酗酒男女的海马体积。所有受试者的年龄在27到53岁之间。通过矢状面t -1加权高分辨率磁共振图像测量海马体积。结果：与酗酒男性相比，酗酒女性终生饮酒较少，且开始重度饮酒的年龄较晚。与同一海域的健康受试者相比，酗酒男性和女性的右侧海马体明显较小，脑脊液体积明显较大。只有女性的左海马体和非海马体的脑容量也明显较小。无论男女，酗酒者和健康者的海马体体积相对于大脑其他部分的比例是相同的。所有受试者的右海马比左海马大。与男性相比，女性表现出更大的海马体积相对于总脑容量。精神合并症，包括创伤后应激障碍，不影响海马体积。结论：慢性酒精中毒患者海马体积的减少与脑体积的减少成正比。在海马体损伤的研究中应该考虑到饮酒。
Background: Smaller hippocampal volumes have been reported in the brains of alcoholic patients than in those of healthy subjects, although it is unclear if the hippocampus is disproportionally smaller than the brain as a whole. There is evidence that alcoholic women are more susceptible than alcoholic men to liver and cardiac damage from alcohol. It is not known whether the hippocampi of the female brain are more vulnerable to alcohol.Methods: We compared the hippocampal volumes in 52 hospitalized alcoholic men and women with those of 36 healthy nonalcoholic men and women. All subjects were between 27 and 53 years of age. The hippocampal volumes were measured from sagittal T-1-weighted high-resolution magnetic resonance images.Results: The alcoholic women had less lifetime drinking and a later age at onset of heavy drinking than alcoholic men. Both alcoholic men and women had significantly smaller right hippocampi and larger cerebrospinal fluid volumes than healthy subjects of the same sea. Only among women were the left hippocampus anti the non-hippocampal brain volume also significantly smaller. The proportion of hippocampal volume relative to the rest of the brain volume was the same in alcoholic patients and healthy subjects, in both men and women. The right hippocampus was larger than the left among all subjects. Women demonstrated larger hippocampal volumes relative to total brain volume than men. Psychiatric comorbidity, including posttraumatic stress disorder, did not affect hippocampal volume.Conclusions: In chronic alcoholism, the reduction of hippocampal volume is proportional to the reduction of the brain volume. Alcohol consumption should he accounted for in studies of hippocampal damage.