Effects of dietary catechins on glucose tolerance, blood pressure and oxidative status in Goto-Kakizaki rats
Effects of dietary catechins on glucose tolerance, blood pressure and oxidative status in Goto-Kakizaki rats
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DOI：
10.3177/jnsv.53.496
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发表时间：
2007-12-01
影响因子：
1.6
通讯作者：
Hara, Yukihiko
中科院分区：
文献类型：
--
作者：
Igarashi, Kiharu;Honma, Keisuke;Hara, Yukihiko
测定了包括EGCg、EGC、ECg、EC、GCg、GC、Cg和C的绿色茶儿茶素对2型糖尿病Goto-Kakizaki（GK）大鼠的血糖耐受和氧化应激状态的影响。GK大鼠喂食含儿茶素的饮食往往保持血糖和收缩压在较低的水平，在后期阶段的喂养期76天，相比，那些没有接受饮食儿茶素（对照组）。在第48-49天进行的血糖耐量试验表明，在葡萄糖负荷后120分钟期间，喂食儿茶素的GK大鼠的血糖水平低于未喂食儿茶素的GK大鼠。在儿茶素喂养的大鼠中，在第71-72天测定的8-011 dG和白蛋白排泄到尿中的量以及在第76天测定的肾ACE活性低于对照大鼠。从这些结果可以得出结论，饮食中的儿茶素可能是有效的延缓糖尿病的进展和相关的氧化应激。
Effects of green tea catechins comprising EGCg, EGC, ECg, EC, GCg, GC, Cg, and C were determined on blood glucose tolerance and oxidative stress status in type 2 diabetic Goto-Kakizaki (GK) rats. GK rats fed the catechin-containing diet tended to maintain blood glucose and systolic blood pressure at lower levels in the latter stages of the feeding period of 76 d, compared to those not receiving dietary catechins (control group). The blood glucose tolerance test performed on days 48-49 showed that GK rats fed the catechins had lower blood glucose levels than GK rats not fed catechins during the 120 min after glucose loading. In catechin-fed rats, amounts of 8-011 dG and albumin excreted into the urine determined on days 71-72, and kidney ACE activity determined on day 76, were lower than those in control rats. From these results it is concluded that dietary catechins may be effective in delaying the progression of diabetes and the associated oxidative stress.