Disruption in prepulse inhibition after alpha-1 adrenoceptor stimulation in rats
Disruption in prepulse inhibition after alpha-1 adrenoceptor stimulation in rats
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DOI：
10.1016/s0028-3908(98)00051-3
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发表时间：
1998-01-01
影响因子：
4.7
通讯作者：
Geyer, MA
中科院分区：
文献类型：
--
作者：
Carasso, BS;Bakshi, VP;Geyer, MA
在大鼠中评价α-1肾上腺素受体在前脉冲抑制（PPI）中的作用。α-1肾上腺素能激动剂cirazoline破坏PPI;这种作用被α-1肾上腺素能拮抗剂哌唑嗪或非典型抗精神病药奎替鲁逆转。因此，α-1肾上腺素受体可能参与PPI的调节和某些抗精神病药物的精神治疗作用。(C)1998爱思唯尔科技有限公司版权所有。
The role of the alpha-1 adrenoceptor in prepulse inhibition (PPI) was evaluated in rats. The alpha-1 adrenergic agonist cirazoline disrupted PPI; this effect was reversed by the alpha-1 adrenergic antagonist prazosin or the atypical antipsychotic quetiapine. Alpha-1 adrenoceptors may thus be involved in the regulation of PPI and in the psychotherapeutic actions of certain antipsychotics. (C) 1998 Elsevier Science Ltd. All rights reserved.