Human hippocampal and parahippocampal theta during goal-directed spatial navigation predicts performance on a virtual Morris water maze
Human hippocampal and parahippocampal theta during goal-directed spatial navigation predicts performance on a virtual Morris water maze
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DOI：
10.1523/jneurosci.5001-07.2008
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发表时间：
2008-06-04
影响因子：
5.3
通讯作者：
Grillon, Christian
中科院分区：
文献类型：
--
作者：
Cornwell, Brian R.;Johnson, Linda L.;Grillon, Christian
在动物和人类的空间导航过程中，海马区和海马区旁皮质表现出theta振荡，前者被认为参与了空间记忆的形成。然而，人类海马theta的功能特异性尚不清楚。当健康参与者在虚拟现实Morris水迷宫中导航到隐藏的平台时，使用全头275通道脑磁图(MEG)系统记录脑磁活动。使用空间滤波技术(即合成孔径磁测法)分析了脑磁图数据，以寻找4-8赫兹频段的潜在振荡源。来源分析显示，与感觉运动控制条件下的无目标运动相比，在目标导向导航过程中，左侧前海马区和海马区旁皮质的theta活性更大。进一步的分析表明，在训练的前半段，主要观察到左侧前海马区的活动，这表明该区域在早期学习中发挥了作用。此外，后海马区的theta与航行成绩高度相关，前者可以解释后者的76%的变异。我们的发现表明，人类的空间学习依赖于海马体和海马体旁的theta振荡，对人类来说，大量研究表明海马体在动物导航中起着如此关键的作用。
The hippocampus and parahippocampal cortices exhibit theta oscillations during spatial navigation in animals and humans, and in the former are thought to mediate spatial memory formation. Functional specificity of human hippocampal theta, however, is unclear. Neuromagnetic activity was recorded with a whole-head 275-channel magnetoencephalographic (MEG) system as healthy participants navigated to a hidden platform in a virtual reality Morris water maze. MEG data were analyzed for underlying oscillatory sources in the 4-8 Hz band using a spatial filtering technique (i.e., synthetic aperture magnetometry). Source analyses revealed greater theta activity in the left anterior hippocampus and parahippocampal cortices during goal-directed navigation relative to aimless movements in a sensorimotor control condition. Additional analyses showed that left anterior hippocampal activity was predominantly observed during the first one-half of training, pointing to a role for this region in early learning. Moreover, posterior hippocampal theta was highly correlated with navigation performance, with the former accounting for 76% of the variance of the latter. Our findings suggest human spatial learning is dependent on hippocampal and parahippocampal theta oscillations, extending to humans a significant body of research demonstrating such a pivotal role for hippocampal theta in animal navigation.