Cp*Rh(III)-Catalyzed ortho-Alkylation/Alkenylation of Nitroarenes.
Cp*Rh(III)-Catalyzed ortho-Alkylation/Alkenylation of Nitroarenes.
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DOI：
10.1021/acs.orglett.3c01614
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发表时间：
2023-07
期刊：
影响因子：
5.2
通讯作者：
Lin Xiao;Xu-Ge Liu;Mei-Zhu Bao;Jia-lin Song;Shaojun Chen;Yi-Chuan Zheng;Yan-Zhi Liu;Shang‐Shi Zhang
中科院分区：
文献类型：
--
作者：
Lin Xiao;Xu-Ge Liu;Mei-Zhu Bao;Jia-lin Song;Shaojun Chen;Yi-Chuan Zheng;Yan-Zhi Liu;Shang‐Shi Zhang
首次报道了 Cp*Rh(III) 催化的硝基导向的硝基芳烃 C-H 烷基化/烯基化反应。该方案具有效率高、底物范围广、官能团兼容性好的特点。此外，克级实验和合成应用证明了该方法的实用性。此外，初步的机理研究一致表明 C-H 键断裂是限速步骤。
Cp*Rh(III)-catalyzed nitro-directed C-H alkylation/alkenylation of nitroarenes has been reported for the first time. This protocol is associated with the features of high efficiency, broad substrate scope, and good functional group compatibility. Additionally, gram-scale experiments and synthetic applications proved the practicability of the method. Moreover, preliminary mechanistic investigations consistently revealed C-H bond cleavage as the rate-limiting step.