Hydrogen Bonding Using NMR: A New Look at the 2,4-Pentanedione Keto-Enol Tautomer Experiment
Hydrogen Bonding Using NMR: A New Look at the 2,4-Pentanedione Keto-Enol Tautomer Experiment
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DOI：
10.1021/ed079p707
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发表时间：
2002-06
影响因子：
3
通讯作者：
T. Zielinski;A. Grushow
中科院分区：
文献类型：
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作者：
T. Zielinski;A. Grushow
对物理化学实验室中的标准酮-烯醇实验提出了一些改进建议，以便使用许多化学系现有的现代核磁共振仪器。这些修改包括样品制备使用氘代溶剂的FT-NMR频率锁定，深入分析的质子光谱获得的中场（~300 MHz）NMR，检查的温度依赖性的平衡过程，和多核调查。远程访问的仪器和随后的数据分析促进了互联网进行了讨论。这些方法允许学生在一个综合的单一实验设计中学习各种各样的概念。我们在分析中包括学生数据，并概述了实验的可能扩展。
A number of modifications to the standard keto–enol experiment in the physical chemistry laboratory are suggested for using modern NMR instruments now available in many chemistry departments. These modifications include sample preparation using a deuterated solvent for FT–NMR frequency locking, in-depth analysis of a proton spectrum acquired with a medium field (~300 MHz) NMR, examination of the temperature dependence of equilibrium processes, and multinuclear investigations. Remote access to the instrument and subsequent data analysis facilitated by the Internet are discussed. These methods permit students to learn about a wide variety of concepts within an integrated single-experiment design. We include student data in our analysis and an overview of possible extensions to the experiment.