The relation of retinal microvascular characteristics to age-related eye disease: The beaver dam eye study
The relation of retinal microvascular characteristics to age-related eye disease: The beaver dam eye study
复制标题
DOI：
10.1016/j.ajo.2003.10.020
复制
发表时间：
2004-03-01
影响因子：
4.2
通讯作者：
Wong, TY
中科院分区：
文献类型：
--
作者：
Klein, R;Klein, BEK;Wong, TY
目的：检查微血管特征（视网膜中央动脉当量[CRAE]、视网膜中央静脉当量[CRVE]、小动脉与小静脉比[AVR]、局灶性视网膜小动脉狭窄、动静脉[A/V]缺口和视网膜病变）与全身性高血压和眼部疾病（年龄相关性黄斑病[ARM]、三种类型的白内障和开角型）之间的关系设计：基于人群的队列研究。方法：对 4,926 名 4,926 名年龄在 43 至 86 岁之间、在基线检查时参加 Beaver Dam Eye 研究的人拍摄的眼底光子图进行微血管特征的标准化分级。在基线时确定与年龄相关的黄斑病、白内障和青光眼状况；使用标准方案在 5 年和 10 年随访检查中再次确定 ARM 和白内障。 结果：在控制年龄和性别的同时，广泛性视网膜小动脉狭窄（CRAE 的最低五分位数）与视网膜色素上皮 (RPE) 脱色的 10 年累积发生率相关（风险比 [RR] 第一与第五五分位数，1.93；95% 置信区间[CI]，1.11，3.34），相反，发生核性白内障（RR，0.71；95% CI，0.50，0.99）。动静脉切口与早期 ARM 的发生率相关（RR，2.39；95% CI，1.02，5.57）。除此之外，局灶性小动脉狭窄或视网膜病变与 ARM 或任何类型的年龄、相关白内障没有统计学上的显着关联，并且 CRAE、局灶性小动脉狭窄、A/V 切口或视网膜病变与青光眼患病率没有关系。结论：这些数据表明，与高血压相关的视网膜血管特征与 ARM 和核性白内障的发生率相关，但与青光眼患病率无关。然而，关系却很脆弱且不稳定。 (C) 2004 年，Elsevier Inc. 保留所有权利。
PURPOSE: To examine the relationship between microvascular characteristics (central retinal artery equivalent [CRAE], central retinal vein equivalent [CRVE], arteriole-to,venule ratio [AVR], focal retinal arteriolar nar rowing, arteriovenous [A/V] nicking, and retinopathy) associated with systemic hypertension and ocular disease (age-related maculopathy [ARM], three types of cataract, and open-angle glaucoma).DESIGN: Population,based cohort study.METHODS: Standardized grading of microvascular characteristics was performed at baseline on fundus photon graphs taken on 4,926 persons aged 43 to 86 years who participated in the Beaver Dam Eye study at the baseline examination. Age-related maculopathy, cataract, and glaucoma status were determined at baseline; ARM and cataract were again determined at 5 year and 10-year follow-up examinations using standard protocols.RESULTS: While controlling for age and sex, generalized retinal arteriolar narrowing (lowest quintile of CRAE) was associated with the 10,year cumulative incidence of retinal pigment epithelial (RPE) depigmentation (risk ratio [RR] 1st vs 5th quintile, 1.93; 95% confidence interval [CI], 1.11, 3.34) and, inversely, with incident nuclear cataract (RR, 0.71; 95% CI, 0.50, 0.99). Arteriovenous nicking was associated with the incidence of early ARM (RR, 2.39; 95% CI, 1.02, 5.57). Otherwise, there were no statistically significant associations of focal arteriolar narrowing or retinopathy with incident ARM or any type of age,related cataract and no relation of CRAE, focal arteriolar narrowing, A/V nicking, or retinopathy with the prevalence of glaucoma.CONCLUSION: These data show that retinal vascular characteristics associated with hypertension are related to the incidence of ARM and nuclear cataract but not to prevalent glaucoma. Relationships, however, were weak and inconsistent. (C) 2004 by Elsevier Inc. All rights reserved.