Association of the aromatase gene with Alzheimer's disease in women
Association of the aromatase gene with Alzheimer's disease in women
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DOI：
10.1016/j.neulet.2009.10.089
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发表时间：
2010-01-14
影响因子：
2.5
通讯作者：
Lehmann, Donald J.
中科院分区：
文献类型：
--
作者：
Butler, Helen T.;Warden, Donald R.;Lehmann, Donald J.
芳香化酶多态性与阿尔茨海默病（AD）的关联已被报道。我们研究了来自OPTIMA队列的207例AD患者、23例轻度认知障碍（MCI）患者和233例对照者的9个多态性。我们重复了两个已报道的关联，并发现了其他关联。我们的研究结果在AD和MCI之间是一致的。此外，我们的结果是性别特异性的，即某些多态性与性别之间存在显著的相互作用，并且与AD的关联几乎完全发生在女性身上。芳香酶催化雄激素向雌激素的转化。它在人脑中表达。在海马体中，它在绝经后妇女中上调，在阿尔茨海默病中降低。因此，这些性别差异的结果是可信的。然而，我们的结果现在需要在更大的数据集中进行复制。2009爱思唯尔爱尔兰有限公司版权所有。
Associations have been reported of aromatase polymorphisms with Alzheimer's disease (AD). We studied nine polymorphisms in 207 cases of AD, 23 cases of mild cognitive impairment (MCI) and 233 controls, all from the OPTIMA cohort. We replicated two reported associations and found others. Our findings were consistent between AD and MCI. Further, our results were sex-specific, i.e. there were significant interactions between certain polymorphisms and gender, and the associations with AD were almost entirely in women. Aromatase catalyses the conversion of androgens to estrogens. It is expressed in the human brain. In the hippocampus, it is upregulated in postmenopausal women and is lowered in AD. These sex-specific results are therefore plausible. However, our results now need to be replicated in a larger dataset. (C) 2009 Elsevier Ireland Ltd. All rights reserved.