STEREOTACTIC BODY RADIOTHERAPY FOR PRIMARY LUNG CANCER AT A DOSE OF 50 GY TOTAL IN FIVE FRACTIONS TO THE PERIPHERY OF THE PLANNING TARGET VOLUME CALCULATED USING A SUPERPOSITION ALGORITHM
STEREOTACTIC BODY RADIOTHERAPY FOR PRIMARY LUNG CANCER AT A DOSE OF 50 GY TOTAL IN FIVE FRACTIONS TO THE PERIPHERY OF THE PLANNING TARGET VOLUME CALCULATED USING A SUPERPOSITION ALGORITHM
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DOI：
10.1016/j.ijrobp.2008.04.043
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发表时间：
2009-02-01
影响因子：
7
通讯作者：
Kubo, Atsushi
中科院分区：
文献类型：
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作者：
Takeda, Atsuya;Sanuki, Naoko;Kubo, Atsushi
目的：回顾性分析立体定向体部放疗（SBRT）的临床结果与1A和1B期非小细胞肺癌cancer.Methods和材料：我们回顾了2001年12月和2007年5月之间的治疗意图与非小细胞肺癌患者的记录。所有患者均有组织病理学或细胞学证实的疾病、肿瘤标志物水平升高和/或氟脱氧葡萄糖正电子发射断层扫描阳性结果。分期研究将他们的疾病确定为1A或1B期。根据世界卫生组织指南，所有病例的体能状态均为2或更低。规定的剂量为50戈伊总在五个分数，通过使用叠加算法计算，被定义为周边的规划目标volume.Results：一百二十一例患者进行SBRT在研究期间，和63有资格进行这项分析。38例患者为1A期（TIN 0 M0），25例患者为1B期（T2 N 0 M0）。49例患者因慢性肺部疾病不适合手术。这49例患者的中位随访时间为31个月（范围：10-72个月）。1A期和1B期患者的3年局部控制率、无病生存率和总生存率分别为93%和96%（p = 0.86）、76%和77%（P = 0.83）以及90%和63%（p = 0.09）。未观察到急性毒性。3例患者发生2级或2级以上放射性肺炎，其中1例发生致命性细菌性肺炎。结论：采用叠加算法计算的计划靶区周围的SBRT，总剂量为50戈伊，分5次进行，是可行的。T2和T1期肿瘤的局部控制率均较高。(c)2009 Elsevier Inc.
Purpose: To retrospectively analyze the clinical outcomes of stereotactic body radiotherapy (SBRT) for patients with Stages 1A and 1B non-small-cell lung cancer.Methods and Materials: We reviewed the records of patients with non-small-cell lung cancer treated with curative intent between Dec 2001 and May 2007. All patients had histopathologically or cytologically confirmed disease, increased levels of tumor markers, and/or positive findings on fluorodeoxyglucose positron emission tomography. Staging studies identified their disease as Stage 1A or 1B. Performance status was 2 or less according to World Health Organization guidelines in all cases. The prescribed dose of 50 Gy total in five fractions, calculated by using a superposition algorithm, was defined for the periphery of the planning target volume.Results: One hundred twenty-one patients underwent SBRT during the study period, and 63 were eligible for this analysis. Thirty-eight patients had Stage 1A (TIN0M0) and 25 had Stage 1B (T2N0M0). Forty-nine patients were not appropriate candidates for surgery because of chronic pulmonary disease. Median follow-up of these 49 patients was 31 months (range, 10-72 months). The 3-year local control, disease-free, and overall survival rates in patients with Stages 1A and 1B were 93% and 96% (p = 0.86), 76% and 77% (P = 0.83), and 90% and 63% (p = 0.09), respectively. No acute toxicity was observed. Grade 2 or higher radiation pneumonitis was experienced by 3 patients, and I of them had fatal bacterial pneumonia.Conclusions: The SBRT at 50 Gy total in five fractions to the periphery of the planning target volume calculated by using a superposition algorithm is feasible. High local control rates were achieved for both T2 and T1 tumors. (c) 2009 Elsevier Inc.