AN INTERLEUKIN-1 LIKE FACTOR STIMULATES BONE-RESORPTION INVITRO
AN INTERLEUKIN-1 LIKE FACTOR STIMULATES BONE-RESORPTION INVITRO
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DOI：
10.1038/306378a0
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发表时间：
1983-01-01
期刊：
影响因子：
64.8
通讯作者：
RUSSELL, RGG
中科院分区：
文献类型：
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作者：
GOWEN, M;WOOD, DD;RUSSELL, RGG
现在许多活性都归因于单核因子白细胞介素 11，包括增强免疫反应、刺激胸腺细胞增殖2、激活 B 细胞3、刺激结缔组织细胞产生蛋白酶和前列腺素4、刺激急性期蛋白的产生5、诱导发烧6 和诱导中性粒细胞增多7。这些活动被认为是由于各种不同的因素造成的，但现在认为可能是由于非常相似（如果不相同）的分子8-11。白细胞介素 1 (IL-1) 一词是用来描述单核细胞/巨噬细胞释放的作用于 T 和 B 淋巴细胞的因子。只有在这个定义被接受后，才表明淋巴细胞以外的靶细胞也受到IL-1的影响。人血单核细胞产物（单核细胞因子，MCF）与类风湿关节炎和牙周病等炎症性疾病的发病机制有关12,13。骨吸收通常是此类疾病的一个特征，并且在局部骨吸收部位经常发现单核细胞。单核细胞条件培养基的初步实验表明，MCF 可以刺激骨吸收14。因此，我们进行了这项研究来验证这些观察结果，并确定纯化的 IL-1 是否可以刺激体外结缔组织分解。
Many activities are now ascribed to the monokine interleukin 11including enhancement of immune responses, stimulation of thymocyte proliferation2, activation of B cells3, stimulation of proteinase and prostaglandin production by connective tissue cells4, stimulation of the production of acute phase proteins5, induction of fever6and the induction of neutrophilia7. These activities were thought to be due to various different factors, but are now considered probably due to very similar, if not identical, molecules8–11. The term interleukin 1 (IL-1) was coined to describe the factor released by monocyte/macrophages which acts on T and B lymphocytes. Only after this definition had been accepted was it shown that target cells other than lymphocytes were affected by IL-1. Products of human blood monocytes (mononuclear cell factor, MCF) have been implicated in the pathogenesis of inflammatory diseases such as rheumatoid arthritis and periodontal disease12,13. Bone resorption is often a feature of such diseases, and monocytes are frequently found at sites of localized bone resorption. Preliminary experiments with monocyte-conditioned medium indicated that MCF could stimulate bone resorption14. We therefore undertook this study to verify these observations and to determine whether purified IL-1 could stimulate connective tissue breakdownin vitro.