The complex relationship of gene duplication and essentiality
The complex relationship of gene duplication and essentiality
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DOI：
10.1016/j.tig.2009.03.001
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发表时间：
2009-04-01
影响因子：
11.4
通讯作者：
McLysaght, Aoife
中科院分区：
文献类型：
--
作者：
Makino, Takashi;Hokamp, Karsten;McLysaght, Aoife
在酵母和线虫中，重复基因在功能上有重叠，因此从基因组中删除一对重复基因中的一个，相较于删除一个单拷贝基因，更不太可能是致命的。相比之下，先前的分析表明，小鼠的重复基因与单拷贝基因一样重要。我们发现，在多细胞生物中，基因重复与必需性之间的关系是复杂的，发育相关基因以及通过全基因组复制而产生的重复基因比其他重复基因更为必需。
In yeast and worm, duplicate genes overlap in function so that deleting one of a pair from the genome is less likely to be lethal than deleting a singleton gene. By contrast, previous analyses showed that mouse duplicate genes were as essential as singletons. We show that the relationship between gene duplication and essentiality is complex in multicellular organisms, with developmental genes and genes that were duplicated by whole genome duplication being more essential than other duplicated genes.