SYMPATHETIC-NERVE ACTIVITY DURING SLEEP IN NORMAL SUBJECTS
SYMPATHETIC-NERVE ACTIVITY DURING SLEEP IN NORMAL SUBJECTS
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DOI：
10.1056/nejm199302043280502
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发表时间：
1993-02-04
影响因子：
158.5
通讯作者：
ABBOUD, FM
中科院分区：
文献类型：
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作者：
SOMERS, VK;DYKEN, ME;ABBOUD, FM
背景清晨醒来后的几个小时与心肌梗死和缺血性中风等事件的频率增加有关。这些事件的触发机制尚不清楚。我们调查了睡眠期间，特别是快速眼动（REM）睡眠期间发生的自主神经变化是否有助于启动此类事件。我们测量了8名正常受试者在清醒和睡眠的5个阶段时的血压、心率和交感神经活动（使用显微神经造影术，它提供了与肌肉血管相关的传出交感神经活动的直接测量）。交感神经活动爆发的平均（+/-SE）幅度以及血压和心率水平显著下降（P
Background. The early hours of the morning after awakening are associated with an increased frequency of events such as myocardial infarction and ischemic stroke. The triggering mechanisms for these events are not clear. We investigated whether autonomic changes occurring during sleep, particularly rapid-eye-movement (REM) sleep, contribute to the initiation of such events.Methods. We measured blood pressure, heart rate, and sympathetic-nerve activity (using microneurography, which provides direct measurements of efferent sympathetic-nerve activity related to muscle blood vessels) in eight normal subjects while they were awake and while in the five stages of sleep.Results. The mean (+/-SE)amplitude of bursts of sympathetic-nerve activity and levels of blood pressure and heart rate declined significantly (P