Intrahippocampal D-cycloserine improves MK-801-induced memory deficits: radial-arm maze performance in rats
Intrahippocampal D-cycloserine improves MK-801-induced memory deficits: radial-arm maze performance in rats
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DOI：
10.1016/s0006-8993(98)01043-9
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发表时间：
1998-12-14
期刊：
影响因子：
2.9
通讯作者：
Iwasaki, T
中科院分区：
文献类型：
--
作者：
Kawabe, K;Yoshihara, T;Iwasaki, T
为了研究士的宁不敏感甘氨酸位点与海马NMDA（N-甲基-D-天冬氨酸）受体偶联是否参与大鼠空间记忆，我们研究了海马内注射甘氨酸位点激动剂D-环丝氨酸（DCS）对NMDA拮抗剂MK-801（地佐环平）引起的大鼠空间记忆障碍的影响。在获得该任务后，在腹膜内MK-801或生理盐水（SAL）和海马内DCS或SAL的组合处理下测试径向迷宫性能。结果表明，MK-801损害了性能，DCS改善了MK-801引起的性能损害。这些结果表明，甘氨酸位点通过对海马NMDA受体的调节作用参与空间记忆。(C)1998 Elsevier Science B. V.保留所有权利。
In order to investigate whether strychnine-insensitive glycine sites coupled with hippocampal NMDA( N-methyl-D-aspartate) receptors are involved in spatial memory in rats, we examined the effects of intrahippocampal treatment of D-cycloserine (DCS), a glycine-site agonist, on spatial-memory deficits which were produced by an NMDA antagonist MK-801 (dizocilpine) on the radial-arm maze task. After the acquisition of this task, the radial-maze performance was tested under the combined treatments of intraperitoneal MK-801 or saline (SAL) and intrahippocampal DCS or SAL. The results showed that MK-801 impaired the performance, and that DCS improved the MK-801-induced performance impairment. These results suggest that glycine sites are involved in spatial memory through their modulatory action on hippocampal NMDA receptors. (C) 1998 Elsevier Science B.V. All rights reserved.