5-MeO-DMT for post-traumatic stress disorder: a real-world longitudinal case study.
5-MeO-DMT for post-traumatic stress disorder: a real-world longitudinal case study.
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DOI：
10.3389/fpsyt.2023.1271152
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发表时间：
2023
影响因子：
4.7
通讯作者：
Averill, Lynnette Astrid
中科院分区：
文献类型：
--
作者：
Ragnhildstveit, Anya;Khan, Ryan;Seli, Paul;Bass, Lisa Claire;August, River Jude;Kaiyo, Miriam;Barr, Nathaniel;Jackson, Laura Kate;Gaffrey, Michael Santo;Barsuglia, Joseph Peter;Averill, Lynnette Astrid
关键词：
可以说，迷幻疗法是精神病学的下一个前沿领域。它为长期以来的主流治疗提供了一种彻底的替代方案，同时也激发了转化科学和药物发现的范式转变。人们对5-甲氧基- n， n -二甲基色胺（5-MeO-DMT）——一种5-羟色胺能致幻剂——作为一种新型的、快速的治疗药物特别感兴趣。然而，很少有研究直接检测5-MeO-DMT与创伤或压力相关的精神病理学，包括创伤后应激障碍（PTSD）。在此，我们提出了第一个纵向病例研究5-MeO-DMT慢性难治性PTSD，在一个23岁的女性。单剂量的索诺兰沙漠蟾蜍（Incilius alvarius）汽化蟾毒素，估计含有10 - 15毫克的5-MeO-DMT，导致PTSD的临床显着改善，并具有第二天的效果。与此同时，绝望情绪和相关自杀风险也显著降低。所有结构的改善在1个月、3个月、6个月和12个月的随访中持续，由一名支持临床医生监测。受试者进一步认可了一种完全神秘的体验，假设这是5-MeO-DMT治疗活性的基础。未发生与药物相关的严重不良事件。总之，结果表明5-MeO-DMT对创伤后应激障碍一般是耐受的，安全的，有效的；然而，这并非没有风险。受试者报告急性恶心，强烈的主观反应，以及晚起的夜惊。进一步的研究需要复制和扩展这些发现，这些发现本身是有限的，不可推广的，并且依赖于临床不接受的方法。
Psychedelic therapy is, arguably, the next frontier in psychiatry. It offers a radical alternative to longstanding, mainstays of treatment, while exciting a paradigm shift in translational science and drug discovery. There is particular interest in 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT)—a serotonergic psychedelic—as a novel, fast-acting therapeutic. Yet, few studies have directly examined 5-MeO-DMT for trauma- or stress-related psychopathology, including post-traumatic stress disorder (PTSD). Herein, we present the first longitudinal case study on 5-MeO-DMT for chronic refractory PTSD, in a 23-year-old female. A single dose of vaporized bufotoxin of the Sonoran Desert Toad (Incilius alvarius), containing an estimated 10−15 mg of 5-MeO-DMT, led to clinically significant improvements in PTSD, with next-day effects. This was accompanied by marked reductions in hopelessness and related suicide risk. Improvements, across all constructs, were sustained at 1-, 3-, 6-, and 12-months follow-up, as monitored by a supporting clinician. The subject further endorsed a complete mystical experience, hypothesized to underly 5-MeO-DMT’s therapeutic activity. No drug-related, serious adverse events occurred. Together, results showed that 5-MeO-DMT was generally tolerable, safe to administer, and effective for PTSD; however, this was not without risk. The subject reported acute nausea, overwhelming subjective effects, and late onset of night terrors. Further research is warranted to replicate and extend these findings, which are inherently limited, non-generalizable, and rely on methods not clinically accepted.
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影响因子：
3.4
作者：
Halberstadt, Adam L.;Nichols, David E.;Geyer, Mark A.
通讯作者：
Geyer, Mark A.
影响因子：
4.7
作者：
Ko, Kwonmok;Knight, Gemma;Rucker, James J.;Cleare, Anthony J.
通讯作者：
Cleare, Anthony J.
影响因子：
2.8
作者：
Glynos, Nicolas G.;Fields, Christopher W.;Boehnke, Kevin F.
通讯作者：
Boehnke, Kevin F.
影响因子：
1
作者：
Gagnier JJ;Kienle G;Altman DG;Moher D;Sox H;Riley D;CARE Group
通讯作者：
CARE Group
DOI：
10.1177/0269881116675513
发表时间：
2016-12
期刊：
Journal of psychopharmacology (Oxford, England)
影响因子：
--
作者：
Griffiths RR;Johnson MW;Carducci MA;Umbricht A;Richards WA;Richards BD;Cosimano MP;Klinedinst MA
通讯作者：
Klinedinst MA