The Cerebellum in Feeding Control: Possible Function and Mechanism
The Cerebellum in Feeding Control: Possible Function and Mechanism
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DOI：
10.1007/s10571-007-9236-z
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发表时间：
2008-06
影响因子：
4
通讯作者：
Jing-Ning Zhu;Jian-jun Wang
中科院分区：
文献类型：
--
作者：
Jing-Ning Zhu;Jian-jun Wang
不断积累的解剖学、功能和行为研究表明，小脑参与各种内脏功能的调节，包括摄食控制。小脑病变可能会导致进食行为改变和体重下降。尽管小脑调节食物摄入的确切机制尚不清楚，但一系列研究表明，存在神经通路直接和/或间接将小脑与下丘脑等几个重要的摄食控制中心连接起来。电生理学数据表明，通过小脑下丘脑的直接投射，小脑输出可能会到达、汇聚并与一些关键的进食信号整合，包括胃迷走神经传入、CCK、瘦素和单个下丘脑神经元上的血糖。此外，最近的功能成像研究提供了大量证据表明饥饿、饱足和口渴伴随着小脑激活。在这里，我们描述小脑可能不仅仅是一个运动协调器，而且积极参与摄食控制，即它可能充当连接躯体和内脏系统的重要节点，并有助于在摄食行为中产生整合和协调的躯体-内脏反应。
Accumulating anatomical, functional, and behavioral studies reveal that the cerebellum is involved in the regulation of various visceral functions including feeding control. Cerebellar lesions may induce alterations in feeding behavior and decreases in body weight. Although the exact mechanisms underlying the cerebellar regulation of food intake is still unclear, a series of studies have demonstrated that there are neural pathways directly and/or indirectly connecting the cerebellum with several important centers for feeding control, such as the hypothalamus. Electrophysiological data suggest that via the direct cerebellohypothalamic projections, the cerebellar outputs may reach, converge, and be integrated with some critical feeding signals including gastric vagal afferents, CCK, leptin, and glycemia on single hypothalamic neurons. Furthermore, recent functional imaging studies provide substantial evidences that hunger, satiation, and thirst are accompanied with a cerebellar activation. Here we describe that the cerebellum may be much more than a movement coordinator and actively participate in feeding control, i.e., it may act as an essential node linking somatic and visceral systems and help to generate an integrated and coordinated somatic-visceral response in feeding behavior.