Clinical significance of serum thioredoxin 1 levels in patients with acute pancreatitis

Clinical significance of serum thioredoxin 1 levels in patients with acute pancreatitis
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DOI：
10.1097/01.mpa.0000203958.93758.bd
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发表时间：
2006-04-01
期刊：
PANCREAS
影响因子：
2.9
通讯作者：
Chiba, Tsutomu
Chiba, Tsutomu
中科院分区：
医学4区
文献类型：
--
作者：
Ohashi, Shinya;Nishio, Akiyoshi;Chiba, Tsutomu

文献摘要

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目的：硫氧还蛋白1（TRX-1）是一种具有抗氧化活性的氧化还原调节蛋白，可由氧化应激诱导，血清TRX-1水平被认为是氧化应激的标志物。本研究的目的是澄清血清TRX-1水平在急性胰腺炎（AP）患者的临床意义，并评估此测量在评估疾病severity.Methods的有用性：血清TRX-1水平测定入院时在18例重症AP和36例轻度AP。结果：入院时血清TRX-1水平在轻度AP和重度AP中分别为54.9 ng/mL和118.8 ng/mL。当TRX-1预测重度AP的临界值确定为100 ng/mL时，其灵敏度、特异性和准确性分别为83.3%、94.4%和90.7%。血清TRX-1水平与AP患者的兰森评分（r = 0.674）、C反应蛋白（r = 0.718）、白细胞计数（r = 0.642）、白细胞介素6（r = 0.712）、血清淀粉酶（r = 0.436）呈显著相关。TRX-1应该构成一个可靠的氧化应激标记物，用于评估AP严重程度与氧化应激的关系。
Objective: Thioredoxin 1 (TRX-1), a redox-regulating protein with antioxidant activity, is induced by oxidative stress, and serum TRX-1 levels are recognized as an oxidative-stress marker. The aim of this study was to clarify the clinical significance of serum TRX-1 levels in patients with acute pancreatitis (AP) and evaluate the usefulness of this measurement in assessing disease severity.Methods: Serum TRX-1 levels were determined on admission in 18 patients with severe AP and 36 patients with mild AP. We also investigated the relationship between serum TRX-1 levels and clinical and laboratory data.Results: The median serum TRX-1 levels on admission were 54.9 ng/mL in mild AP and 118.8 ng/mL in severe AP. When the cutoff value for TRX-1 in predicting severe AP was determined to be 100 ng/mL, its sensitivity, specificity, and accuracy were 83.3%, 94.4%, and 90.7%, respectively. A significant correlation was observed between serum TRX-1 levels and Ranson score (r = 0.674), C-reactive protein (r = 0.718), interieukin 6 (r = 0.712) leukocyte count (r = 0.642), and serum amylase (r = 0.436).Conclusions: Serum TRX-1 levels significantly correlate with AP severity. TRX-1 should constitute a reliable oxidative-stress marker for the evaluation of AP severity in relation to oxidative stress.