Open field behavior of C57BL/6J mice as a function of age, experience, and prenatal maternal stress
Open field behavior of C57BL/6J mice as a function of age, experience, and prenatal maternal stress
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C57BL/6J 小鼠的旷场行为与年龄、经验和产前母亲压力的关系
DOI：
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发表时间：
1964
期刊：
影响因子：
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通讯作者：
M. W. Weir
中科院分区：
文献类型：
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作者：
J. Defries;M. W. Weir
为了评估年龄、既往试验经验和产前母体应激对旷场行为的作用，将应激（处理）和对照窝仔分为两组。第1组在40和120日龄时在旷场进行测试，第2组仅在120日龄时进行测试。活动水平和位置的比较，在开放领域的幼稚SS在40天的年龄与幼稚SS在120天的年龄表现出显着的年龄效应。同样，这些行为的经验丰富的SS在120天与那些天真的SS在同一年龄的比较，表明以前的测试经验的影响。此外，年龄和先前的测试经验与产前压力的影响可能的相互作用。这些研究结果的重要性，在几个不同年龄的实验变量的影响进行了研究的设计进行了讨论。
In order to assess the role of age, prior test experience and prenatal maternal stress on open-field behavior, both stressed (treated) and control litters were divided into two groups. Group 1 was tested in the open field at both 40 and 120 days of age, and Group 2 at only 120 days. Comparison of activity level and location of activity in the open field of naive Ss at 40 days of age with those of naive Ss at 120 days of age demonstrated significant age effects. Similarly, comparisons of these behaviors of experienced Ss at 120 days with those of naive Ss at the same age, indicated effects of prior test experience. In addition, possible interactions of both age and prior test experience with the effects of prenatal stress were indicated. The importance of these findings for the design of studies in which the effects of experimental variables are examined at several different ages is discussed.