Listeria monocytogenes, a unique model in infection biology: an overview
Listeria monocytogenes, a unique model in infection biology: an overview
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DOI：
10.1016/j.micinf.2008.07.043
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发表时间：
2008-07-01
影响因子：
5.8
通讯作者：
Toledo-Arana, Alejandro
中科院分区：
文献类型：
--
作者：
Cossart, Pascale;Toledo-Arana, Alejandro
这篇综述不是涵盖整个领域，而是旨在强调最近的发现油单核细胞增生李斯特菌感染过程或一些李斯特菌的特定特征，将它们置于完善的数据框架内，并展示这种革兰氏阳性菌如何在二十年内成为一个多方面的范例。事实上，感染过程的细胞生物学已经被非常详细地破译，并提供了细菌病原体操纵宿主的方式和众所周知的细胞蛋白质的未知功能的见解。细胞内和细胞间的运动，特别是在理解肌动蛋白为基础的运动一般是有用的。两种主要的李斯特菌入侵蛋白及其宿主特异性的分析说明了体外研究如何帮助生成或选择相关的动物模型进行体外研究。李斯特菌后基因组学研究突出了比较基因组学在毒力研究中的作用。总之，李斯特菌在被认为是免疫学中的强大工具之后，现在似乎是感染生物学中最有见地的模型之一。(C)2008年，Elsevier Masson SAS。All rights reserved.
This review rather than covering the whole field intends to highlight recent findings oil the Listeria monocytogenes infectious process or some Listeria specific traits, place them within the framework of well-established data, and demonstrate how this Gram-positive bacterium has, in two decades, emerged as a multifaceted paradigm. Indeed, the cell biology of the infectious process has been deciphered in great detail and provided insights in both the way bacteria] pathogen manipulate the host and unsuspected functions of well-known cellular proteins. The intra- and intercellular motility has in particular been instrumental in understanding actin-based motility in general. The analysis of the two main Listeria invasion proteins and that of their host specificities have illustrated how in vitro studies can help generating or choosing relevant animal models for in vitro studies. Listeria post-genomics studies have highlighted the power of comparative genomics in virulence Studies. Together, Listeria, after being recognized as a powerful tool in immunology, now appears as one of the most insightful models in infection biology. (C) 2008 Elsevier Masson SAS. All rights reserved.