STUDIES ON ANTIALLERGIC COMPONENTS IN THE ROOTS OF ASIASARUM-SIEBOLDI
STUDIES ON ANTIALLERGIC COMPONENTS IN THE ROOTS OF ASIASARUM-SIEBOLDI
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DOI：
10.1055/s-2006-959432
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发表时间：
1994-04-01
期刊：
影响因子：
2.7
通讯作者：
FUJITA, T
中科院分区：
文献类型：
--
作者：
HASHIMOTO, K;YANAGISAWA, T;FUJITA, T
已在各种体外和体内实验模型中评估了亚洲草根的甲醇提取物的抗过敏作用。在生物测定指导下对甲醇提取物进行分级分离，在 PCA 测试中分离出抑制性化合物：甲基丁子香酚 (1)、榄香素 (2)、γ-细辛脑 (3)、(-)-细辛素 (4) 和 (-)-芝麻素 (5)。此外，还发现榄香素 (2) 和 (2E,4E,8Z,10E)-N-异丁基-2,4,8,10-十二碳四烯酰胺 (6) 对 RBL-1 细胞的 5-脂氧合酶 (5-LOX) 表现出抑制作用。 3',4'-二甲氧基肉桂醛 (7) 和 xantoxylol (8) 有效降低豚鼠回肠条对 LTD(4) 的收缩反应。
The methanolic extract of the roots of Asiasarum sieboldi has been evaluated for anti-allergic effects on various experimental models in vitro and in vivo. Bioassay-guided fractionation of the methanolic extract resulted in isolation of suppressive compounds in the PCA test: methyleugenol (1), elemicin (2), gamma-asarone (3), (-)-asarinin (4), and (-)-sesamin (5). Furthermore, elemicin (2) and (2E,4E,8Z,10E)-N-isobutyl-2,4,8,10-dodecatetraenamide (6) were found to exhibit an inhibitory action on 5-lipoxygenase (5-LOX) from RBL-1 cells. 3',4'-Dimethoxycinnamaldehyde (7) and xanthoxylol (8) potently reduced the contractile response of guinea pig ileal strips to LTD(4).