ACTIVITY OF INSITU MIDDLE CERVICAL-GANGLION NEURONS IN DOGS, USING EXTRACELLULAR RECORDING TECHNIQUES
ACTIVITY OF INSITU MIDDLE CERVICAL-GANGLION NEURONS IN DOGS, USING EXTRACELLULAR RECORDING TECHNIQUES
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DOI：
10.1139/y85-116
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发表时间：
1985-01-01
影响因子：
2.1
通讯作者：
ARMOUR, JA
中科院分区：
文献类型：
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作者：
ARMOUR, JA
用细胞外记录技术研究了狗颈中神经节神经元的活动。记录的动作电位经常活跃在特定阶段的心动周期，特别是在收缩期，这种活动持续急性分散的神经节。当异丙肾上腺素、去甲肾上腺素、肾上腺素[去甲肾上腺素和肾上腺素]或主动脉部分闭塞改变全身动脉压时，这些动作电位的活性发生改变，无论是在完整的还是急性分散的制备中。这些神经元在收缩压70和180 mmHg（1 mmHg = 133.322 Pa）之间活跃。动作电位经常被修改的机械扭曲的上级腔静脉，心室心外膜，或外膜的主动脉，是否准备是急性分散或没有。在这些动作电位中，70%不受心肺神经刺激（1 ms，4 V，0.5 Hz）的影响，27%受到这种刺激的抑制。其中五个神经元被这种刺激激活。后者神经元在心肺神经中具有轴突，并且最有可能是传出交感节后神经元。在这些自发活动的锁相单位中，63%的单位是通过刺激支或袢而改变的。颈中神经节中的一些神经元可以被来自胸部器官中的受体的传入轴突所修饰，特别是来自大血管和心脏，无论是在完整的还是急性分散的制备中。这些神经元中的大多数被认为不是传入神经元，因为它们不被心肺神经中轴突的电刺激直接激活。相反，它们被认为是中间神经元。与胸心血管动力学相关的神经元活动的相当大的整合发生在犬的颈中神经节内。
Neuronal activity in the in situ middle cervical ganglion of dogs was investigated using extracellular recording techniques. The recorded action potentials were frequently active during specific phases of the cardiac cycle, particularly during systole, and this activity persisted following acute decentralization of the ganglion. The activity of these action potentials was modified when systemic arterial pressure was altered by isoproterenol, noradrenaline, adrenaline [norepinephrine and epinephrine], or partial occlusion of the aorta, whether in the intact or acutely decentralized preparation. These neurons were active between systolic pressures of 70 and 180 mmHg (1 mmHg = 133.322 Pa). Action potentials were frequently modified by mechanical distortion of the superior vena cava, ventricular epicardium, or adventitia of the aorta, whether the preparation was acutely decentralized or not. Of these action potentials 70% were unaffected by stimulation (1 ms, 4 V, 0.5 Hz) of a cardiopulmonary nerve and 27% were suppressed by such stimulation. Five of the neurons were activated by such stimulation. The latter neurons had axons in a cardiopulmonary nerve and most likely were efferent sympathetic postganglionic neurons. Of these spontaneously active phase-locked units 63% were modified by stmiulation of a ramus or an ansa. Some of the neurons in the middle cervical ganglia can be modified by afferent axons arising from receptors in thoracic organs, in particular from the great vessels and heart, whether in an intact or acutely decentralized preparation. The majority of these neurons are presumed not to be afferent neurons, as they are not activated directly by electrical stimulation of axons in cardiopulmonary nerves. Rather they are presumed to be interneurons. Considerable integration of neuronal activity related to thoracic cardiovascular dynamics occurs within the middle cervical ganglia of dogs.