Cytochrome P450 Metabolism of Polyunsaturated Fatty Acids and Neurodegeneration.
Cytochrome P450 Metabolism of Polyunsaturated Fatty Acids and Neurodegeneration.
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细胞色素P450多不饱和脂肪酸代谢与神经退行性变
DOI：
10.3390/nu12113523
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发表时间：
2020-11-16
期刊：
影响因子：
5.9
通讯作者：
Lee KSS
中科院分区：
文献类型：
--
作者：
Sarparast M;Dattmore D;Alan J;Lee KSS
由于世界人口老龄化，神经退行性疾病已成为严重的公共卫生问题，极大地影响了患者的生活质量并增加了巨大的经济负担。即使经过几十年的研究，也没有有效的治疗神经退行性疾病的方法。多不饱和脂肪酸（PUFA）已成为一种新兴的膳食医学干预措施，用于维持健康和治疗疾病，包括神经退行性疾病。最近的研究表明，PUFAs的氧化代谢产物，特别是细胞色素P450（CYP 450）代谢产物，对包括阿尔茨海默病和帕金森病在内的几种神经退行性疾病有益;然而，其机制尚不清楚。内源性代谢产物的水平受我们的饮食、内源性合成和下游代谢的影响很大。虽然ω-3（ω-3）ω PUFA代谢物和ω-6（ω-6）ω PUFA代谢物的活性在很大程度上重叠，但ω-3 ω PUFA代谢物通常更有活性。在这篇综述中，我们将简要总结最近的研究结果，关于生物合成和代谢的多不饱和脂肪酸代谢物。我们还将讨论PUFA代谢产物在神经退行性疾病中的潜在机制，这将最终提高我们对PUFA如何影响神经退行性疾病的理解，并可能确定神经退行性疾病的潜在药物靶点。
Due to the aging population in the world, neurodegenerative diseases have become a serious public health issue that greatly impacts patients’ quality of life and adds a huge economic burden. Even after decades of research, there is no effective curative treatment for neurodegenerative diseases. Polyunsaturated fatty acids (PUFAs) have become an emerging dietary medical intervention for health maintenance and treatment of diseases, including neurodegenerative diseases. Recent research demonstrated that the oxidized metabolites, particularly the cytochrome P450 (CYP) metabolites, of PUFAs are beneficial to several neurodegenerative diseases, including Alzheimer’s disease and Parkinson’s disease; however, their mechanism(s) remains unclear. The endogenous levels of CYP metabolites are greatly affected by our diet, endogenous synthesis, and the downstream metabolism. While the activity of omega-3 (ω-3) CYP PUFA metabolites and omega-6 (ω-6) CYP PUFA metabolites largely overlap, the ω-3 CYP PUFA metabolites are more active in general. In this review, we will briefly summarize recent findings regarding the biosynthesis and metabolism of CYP PUFA metabolites. We will also discuss the potential mechanism(s) of CYP PUFA metabolites in neurodegeneration, which will ultimately improve our understanding of how PUFAs affect neurodegeneration and may identify potential drug targets for neurodegenerative diseases.
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影响因子：
64.8
作者：
通讯作者：
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影响因子：
20.1
作者：
Akao, M;Ohler, A;Marbán, E
通讯作者：
Marbán, E
DOI：
10.1152/ajprenal.1999.277.5.f790
发表时间：
1999-11-01
影响因子：
4.2
作者：
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Roman, RJ
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通讯作者：
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