Cell membrane-derived nanomaterials for biomedical applications.
Cell membrane-derived nanomaterials for biomedical applications.
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DOI：
10.1016/j.biomaterials.2017.02.041
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发表时间：
2017-06
期刊：
影响因子：
14
通讯作者：
Zhang L
中科院分区：
文献类型：
--
作者：
Fang RH;Jiang Y;Fang JC;Zhang L
生物医学纳米技术的持续发展使临床医生能够更好地检测，预防，管理和治疗人类疾病。为了进一步推动纳米颗粒性能和功能的极限，最近出现了向仿生设计策略的范式转变。通过从大自然中汲取灵感，我们的目标是创建下一代纳米粒子平台，可以更有效地导航并与体内存在的令人难以置信的复杂生物系统进行交互。细胞膜在生物界面、自我识别、信号转导和区室化中起着重要作用。在这篇综述中，我们探讨了研究人员直接利用细胞膜衍生生物材料制造新型纳米治疗和纳米诊断的主要方法。这些新兴技术有可能大大推进纳米医学领域，帮助改进传统模式，同时也实现新的应用。
The continued evolution of biomedical nanotechnology has enabled clinicians to better detect, prevent, manage, and treat human disease. In order to further push the limits of nanoparticle performance and functionality, there has recently been a paradigm shift towards biomimetic design strategies. By taking inspiration from nature, the goal is to create next-generation nanoparticle platforms that can more effectively navigate and interact with the incredibly complex biological systems that exist within the body. Of great interest are cellular membranes, which play essential roles in biointerfacing, self-identification, signal transduction, and compartmentalization. In this review, we explore the major ways in which researchers have directly leveraged cell membrane-derived biomaterials for the fabrication of novel nanotherapeutics and nanodiagnostics. Such emerging technologies have the potential to significantly advance the field of nanomedicine, helping to improve upon traditional modalities while also enabling novel applications.