Changes in venous return parameters associated with univentricular Fontan circulations
Changes in venous return parameters associated with univentricular Fontan circulations
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DOI：
10.1152/ajpheart.2000.279.5.h2335
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发表时间：
2000-11-01
影响因子：
4.8
通讯作者：
Neveux, JY
中科院分区：
文献类型：
--
作者：
Macé, L;Dervanian, P;Neveux, JY
To clarify the physiology of venous return (Q(vr)) in Fontan circulations, venous return conductance (G(vr)) and mean circulatory filling pressure (P-mcf) were determined in pentobarbital sodium-anesthetized pigs. Relationships between Q(vr) and right (biventricular, n = 8) or left (Fontan, n = 8) filling pressures are described by straight lines with significant correlation coefficients. Estimated P-mcf values were correlated with observed P-mcf values in either circulations (P less than or equal to 0.02). G(vr) was smaller in Fontan than in biventricular circulations (4.51 +/- 0.36 vs. 7.83 +/- 0.69 ml.min(-1).kg(-1).mmHg(-1), P = 0.002) and inversely correlated with pulmonary vascular resistances in Fontan circulations (P = 0.01). Estimated P-mcf (20.5 +/- 1.4 vs. 11.1 +/- 0.9 mmHg, P = 0.001) and observed P-mcf (21.8 +/- 1.3 vs. 10.6 +/- 0.8 mmHg, P < 0.001) were higher in Fontan versus biventricular circulations, respectively. Pulmonary artery pressure in Fontan circulations was correlated with either P-mcf (P 0.04). We conclude that in Fontan circulations 1) pulmonary vascular resistances induce a proportional decrease in G(vr); and 2) volume loading, while increasing P-mcf (similar to pulmonary artery pressure), allows the gradient for Q(vr) to increase and maintains systemic blood flow at a biventricular level.
