Prefrontal cortex and working memory processes
Prefrontal cortex and working memory processes
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DOI：
10.1016/j.neuroscience.2005.07.003
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发表时间：
2006-01-01
期刊：
影响因子：
3.3
通讯作者：
Funahashi, S
中科院分区：
文献类型：
--
作者：
Funahashi, S
工作记忆是一种对信息进行短时主动保持和加工的机制。背外侧前额叶皮层参与工作记忆。当猴子执行各种工作记忆任务时，对任务相关的背外侧前额叶皮层活动的分析表明，延迟期活动是暂时主动维持信息的机制的神经相关物，因为这种活动在整个延迟期持续存在，对特定的视觉特征表现出选择性，并且与正确的行为表现有关。信息处理可以被认为是在试验过程中由神经活动群体所代表的信息的变化。利用任务相关的背外侧前额叶皮层活动群体计算的群体向量，我们证明了空间工作记忆任务执行过程中背外侧前额叶皮层活动群体所代表的信息的时间变化。互相关分析使用同时分离的神经元对的尖峰放电揭示了相邻神经元（特别是具有延迟期活动的神经元）之间的广泛的功能性相互作用，以及它们取决于试验环境的动态调制。神经元之间的功能相互作用及其动态调制可能是背外侧前额叶皮层信息加工的一种机制。(C)2005年由Elsevier Ltd代表IBRC出版。
Working memory is a mechanism for short-term active maintenance of information as well as for processing maintained information. The dorsolateral prefrontal cortex has been known to participate in working memory. The analysis of task-related dorsolateral prefrontal cortex activity while monkeys performed a variety of working memory tasks revealed that delay-period activity is a neural correlate of a mechanism for temporary active maintenance of information, because this activity persisted throughout the delay period, showed selectivity to a particular visual feature, and was related to correct behavioral performances. Information processing can be considered as a change of the information represented by a population of neural activities during the progress of the trial. Using population vectors calculated by a population of task-related dorsolateral prefrontal cortex activities, we demonstrated the temporal change of information represented by a population of dorsolateral prefrontal cortex activities during performances of spatial working memory tasks. Cross-correlation analysis. using spike firings of simultaneously isolated pairs of neurons reveals widespread functional interactions among neighboring neurons, especially neurons having delay-period activity, and their dynamic modulation depending on the context of the trial. Functional interactions among neurons and their dynamic modulation could be a mechanism of information processing in the dorsolateral prefrontal cortex. (C) 2005 Published by Elsevier Ltd on behalf of IBRC.