Ileal brake: neuropeptidergic control of intestinal transit.
Ileal brake: neuropeptidergic control of intestinal transit.
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DOI：
10.1007/s11894-006-0021-9
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发表时间：
2006-10-01
影响因子：
--
通讯作者：
Lin, Henry C
中科院分区：
文献类型：
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作者：
Van Citters, Gregg W;Lin, Henry C
食物的消化和吸收是一个时间密集型的过程。为了优化消化和吸收，膳食通过胃肠道的转运由神经肽能信号的复杂整合来调节，所述神经肽能信号作为空肠制动和回肠制动对营养物的响应而产生。参与转运反应减慢的介体包括肽YY（PYY）、化学敏感性传入神经元、离体神经、去甲肾上腺素能神经、肌间肾上腺素能神经元和阿片样物质神经元。该回路的激活修改蠕动反射以将肠运动模式从传播转换为分段。脂肪是这些转运控制机制中最有效的触发因素。本文综述了肠道肽和神经元参与营养素转运控制的集成电路。
Digestion and absorption of a meal are time-intensive processes. To optimize digestion and absorption, transit of the meal through the gastrointestinal tract is regulated by a complex integration of neuropeptidergic signals generated as the jejunal brake and ileal brake response to nutrients. Mediators involved in the slowing of transit responses include peptide YY (PYY), chemosensitive afferent neurons, intestinofugal nerves, noradrenergic nerves, myenteric serotonergic neurons, and opioid neurons. The activation of this circuitry modifies the peristaltic reflex to convert the intestinal motility pattern from propagative to segmenting. Fat is the most potent trigger of these transit control mechanisms. The integrated circuitry of gut peptides and neurons involved in transit control in response to nutrients is described in this review.