Toxoplasma gondii: the changing paradigm of congenital toxoplasmosis.
Toxoplasma gondii: the changing paradigm of congenital toxoplasmosis.
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DOI：
10.1017/s0031182011001478
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发表时间：
2011-12-01
期刊：
影响因子：
2.4
通讯作者：
Dubey, J P
中科院分区：
文献类型：
--
作者：
Lindsay, D S;Dubey, J P
在过去的20年里，研究人员对刚地弓形虫的种群生物学有了很多了解。现在很明显，除了首先从欧洲和美国的样本中描述的典型的3种基因型（I型、II型和III型）外，还存在许多非典型基因型。这些基因型在致病性和传播性方面与过去70年来在大多数科学研究中使用的典型基因型不同。这些差异在很大程度上影响了我们过去认为的先天性弓形虫病（CT）的事实，并将在制定预防CT和监测有患CT风险的妇女的新建议方面发挥重要作用。本综述重点介绍了关于弓形虫基因型的新信息，以及这些信息将如何改变我们向孕妇、医生和学生传达CT信息的方式。
Researchers have learned much concerning the population biology of Toxoplasma gondii over the past 2 decades. It is now apparent that many atypical genotypes exist besides the typical 3 genotypes (type I, type II and type III) first described from samples from Europe and the United States. These genotypes can differ in pathogenicity and transmissibility from the typical genotypes that have been used in the majority of scientific research over the past 70 years. These differences impact much of what we used to believe as facts about congenital toxoplasmosis (CT) and will be important in developing new recommendations for prevention of CT and the monitoring of women at risk for developing CT. The present review highlights new information on T. gondii genotypes and how this information will change the way we convey information about CT to pregnant women, physicians and students.