Ventrolateral preoptic nucleus contains sleep-active, galaninergic neurons in multiple mammalian species
Ventrolateral preoptic nucleus contains sleep-active, galaninergic neurons in multiple mammalian species
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DOI：
10.1016/s0306-4522(02)00308-1
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发表时间：
2002-01-01
期刊：
影响因子：
3.3
通讯作者：
Saper, CB
中科院分区：
文献类型：
--
作者：
Gaus, SE;Strecker, RE;Saper, CB
腹外侧视前核（VLPO）是一组在大鼠下丘脑中发现的睡眠活跃神经元，被认为在睡眠期间抑制主要的上行单胺能唤醒系统； VLPO 损伤会导致失眠。除了睡眠期间 Fos 的表达之外，由于缺乏该细胞群的标记物，其他物种中 VLPO 的鉴定变得复杂。我们现在报道，在夜间啮齿动物（小鼠和大鼠）、昼间啮齿动物（八齿鼠）和猫中，高比例的睡眠活跃（表达 Fos）VLPO 神经元表达抑制性神经肽甘丙肽的 mRNA。在昼行性和夜间性猴以及人类的视前区腹外侧区域中，同源的（即含有甘丙肽 mRNA 的细胞群）是可以明显区分的。甘丙肽的表达可能有助于识别哺乳动物大脑腹外侧视前区的睡眠活跃神经元。VLPO 似乎是多个物种睡眠回路的关键组成部分，我们假设 VLPO 随着年龄的增长而缩小，这可能解释了老年人的睡眠缺陷。 (C) 2002 国际广播组织。由爱思唯尔科学有限公司出版。保留所有权利。
The ventrolateral preoptic nucleus (VLPO) is a group of sleep-active neurons that has been identified in the hypothalamus of rats and is thought to inhibit the major ascending monoaminergic arousal systems during sleep; lesions of the VLPO cause insomnia. Identification of the VLPO in other species has been complicated by the lack of a marker for this cell population, other than the expression of Fos during sleep. We now report that a high percentage of the sleep-active (Fos-expressing) VLPO neurons express mRNA for the inhibitory neuropeptide, galanin, in nocturnal rodents (mice and rats), diurnal rodents (degus), and cats. A homologous (i.e. galanin mRNA-containing cell group) is clearly distinguishable in the ventrolateral region of the preoptic area in diurnal and nocturnal monkeys, as well as in humans. Galanin expression may serve to identify sleep-active neurons in the ventrolateral preoptic area of the mammalian brain.The VLPO appears to be a critical component of sleep circuitry across multiple species, and we hypothesize that shrinkage of the VLPO with advancing age may explain sleep deficits in elderly humans. (C) 2002 IBRO. Published by Elsevier Science Ltd. All rights reserved.