Suppression of Migration and Invasion of PC3 Prostate Cancer Cell Line via Activating E-Cadherin Expression by Small Activating RNA
Suppression of Migration and Invasion of PC3 Prostate Cancer Cell Line via Activating E-Cadherin Expression by Small Activating RNA
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小激活RNA激活E-钙粘蛋白表达抑制PC3前列腺癌细胞系的迁移和侵袭
DOI：
10.3109/07357900802620844
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发表时间：
2010-12-01
影响因子：
2.4
通讯作者：
Xie, Liping
中科院分区：
文献类型：
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作者：
Mao, Qiqi;Zheng, Xiangyi;Xie, Liping
小激活RNA是最近发现的一组小的、非编码的双链RNA分子，它们可以通过靶向基因启动子区域诱导序列特异性转录基因激活。在本研究中，我们证明了通过小激活RNA诱导E-cadherin表达可以抑制PC3前列腺癌细胞的迁移和侵袭。抑制作用与β -catenin从细胞核到质膜的再定位和β -catenin介导的反活化减少有关。这些数据表明，通过小激活RNA激活e -钙粘蛋白可能对前列腺癌和其他类型的癌症有治疗作用。
ABSTRACT Small activating RNAs are a recently discovered group of small, noncoding, and double-stranded RNA molecules that can induce sequence-specific transcriptional gene activation by targeting gene promoter regions. In the present study, we demonstrate that induction of E-cadherin expression by small activating RNA leads to suppression of migration and invasion of PC3 prostate cancer cells. The inhibitory effect was associated with relocalization of β -catenin from the nucleus to the plasma membrane and decreased β -catenin-mediated transactivation. These data suggest that activation of E-cadherin by small activating RNA may have a therapeutic benefit for prostate and other types of cancer.