Drivers of Inflammation in Psoriatic Arthritis: the Old and the New
Drivers of Inflammation in Psoriatic Arthritis: the Old and the New
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银屑病关节炎炎症的驱动因素：新旧
DOI：
10.1007/s11926-021-01005-x
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发表时间：
2021-06-01
影响因子：
5
通讯作者：
Kirkham, Bruce W.
中科院分区：
文献类型：
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作者：
O'Brien-Gore, Charlotte;Gray, Elizabeth H.;Kirkham, Bruce W.
综述目的IL-17是由许多淋巴样细胞而不是CD 4+辅助性T细胞（Th 17）产生的认识提高了IBD/银屑病/SpA中新致病途径的可能性。我们回顾最近的知识有关的作用，非常规和常规的淋巴细胞表达IL-17在人类PsA和axSpA。最新发现先天样淋巴细胞，即γ δ（γ δ）T细胞，不变的自然杀伤T（iNKT）细胞和粘膜相关的不变T（MAIT）细胞，以及先天淋巴细胞（ILC）被发现在PsA/SpA的疾病部位。这些细胞通常偏向于17型，并可能显著促进IL-17的产生。利用细胞因子如IL-7和IL-9的非IL-23依赖性IL-17产生途径也刺激这些细胞。传统的CD 4和CD 8淋巴细胞在疾病部位均显示致病性表型。多种先天性样淋巴样细胞和常规淋巴细胞有助于IL-17介导的PsA/SpA病理。这些细胞对非常规免疫和非免疫刺激的反应可以解释这些疾病的特征性临床特征和Jak抑制剂等疗法的潜在治疗机制。
Purpose of Review The recognition that IL-17 is produced by many lymphoid-like cells other than CD4+ T helper (Th17) cells raises the potential for new pathogenic pathways in IBD/psoriasis/SpA. We review recent knowledge concerning the role of unconventional and conventional lymphocytes expressing IL-17 in human PsA and axSpA. Recent Findings Innate-like lymphoid cells, namely gamma delta (gamma delta) T-cells, invariant natural killer T (iNKT) cells and mucosal-associated invariant T (MAIT) cells, together with innate lymphoid cells (ILCs) are found at sites of disease in PsA/SpA. These cells are often skewed to Type-17 profiles and may significantly contribute to IL-17 production. Non-IL-23 dependent IL-17 production pathways, utilising cytokines such as IL-7 and IL-9, also characterise these cells. Both conventional CD4 and CD8 lymphocytes show pathogenic phenotypes at sites of disease. A variety of innate-like lymphoid cells and conventional lymphocytes contribute towards IL-17-mediated pathology in PsA/SpA. The responses of these cells to non-conventional immune and non-immune stimuli may explain characteristic clinical features of these diseases and potential therapeutic mechanisms of therapies such as Jak inhibitors.