Sex-Specific Metabolic Changes in Peripheral Organs of Diabetic Mice
Sex-Specific Metabolic Changes in Peripheral Organs of Diabetic Mice
复制标题
糖尿病小鼠周围器官的性别特异性代谢变化
DOI：
10.1021/acs.jproteome.0c00049
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发表时间：
2020
影响因子：
4.4
通讯作者：
Gao Hongchang
中科院分区：
文献类型：
--
作者：
Zhang Xi;Xu Hangying;Ning Jie;Ji Hui;Yan Junjie;Zheng Yafei;Xu Qingqing;Li Chen;Zhao Liangcai;Zheng Hong;Gao Hongchang
糖尿病(DM)可引起全身代谢紊乱，但性别对DM相关代谢改变的影响鲜有报道。在这里，我们通过基于~1H核磁共振的代谢组学方法，分析了从正常到糖尿病的雄性和雌性小鼠心脏、肝脏和肾脏的代谢变化，目的是研究糖尿病及其并发症发生和发展的性别特异性代谢机制。我们的结果表明，从正常到糖尿病，雄性小鼠比雌性小鼠有更明显的代谢紊乱。此外，在糖尿病的发展过程中，肾脏被发现是代谢紊乱的主要器官，其次是肝脏和心脏。这些改变的代谢物主要参与能量代谢以及氨基酸、胆碱和核苷酸的代谢。因此，本研究认为肾脏是糖尿病的主要器官，并具有性别特异性，为糖尿病肾脏疾病的发病机制提供了不同性别的代谢观点。
Diabetes mellitus (DM) can cause systemic metabolic disorders, but the impact of gender on DM-related metabolic changes is rarely reported. Herein, we analyzed metabolic alterations in the heart, liver, and kidney of male and female mice from normal to diabetes via a1H NMR-based metabolomics method and aimed to investigate sex-specific metabolic mechanisms underlying the onset and development of diabetes and its complications. Our results demonstrate that male mice had more significant metabolic disorders from normal to diabetes than female mice. Moreover, the kidney was found as the major organ of metabolic disorders during the development of diabetes, followed by the liver and heart. These altered metabolites were mainly implicated in energy metabolism as well as amino acid, choline, and nucleotide metabolism. Therefore, this study suggests that the kidney is the primary organ affected by diabetes in a sex-specific manner, which provides a metabolic view on the pathogenesis of diabetic kidney diseases between genders.