Current status of interleukin-10 and regulatory T-cells in cancer.
Current status of interleukin-10 and regulatory T-cells in cancer.
复制标题
DOI：
10.1097/cco.0000000000000006
复制
发表时间：
2013-11
影响因子：
3.4
通讯作者：
Khazaie K
中科院分区：
文献类型：
--
作者：
Dennis KL;Blatner NR;Gounari F;Khazaie K
肿瘤生长会引起抗原特异性的细胞毒反应和免疫抑制反应。白介素10(IL-10)是由调节性T细胞(Tregs)和辅助性T细胞(TH)产生的一种重要的免疫抑制细胞因子。在这里，我们综述了影响癌症免疫病理的IL-10的多效性功能。随着对其免疫刺激功能的了解，IL-10在癌症中的作用变得不太确定。IL-10是T辅助细胞功能、T细胞免疫监测和抑制癌症相关炎症所必需的。通过促进肿瘤特异性免疫监视和抑制致病炎症，IL-10正在成为宿主抗癌斗争中的关键细胞因子。IL-10在肿瘤免疫刺激和免疫抑制的十字路口发挥作用。IL-10的免疫学作用机制最终可以被用来开发新的有效的癌症治疗方法。
Tumor growth elicits antigen-specific cytotoxic as well as immune suppressive responses. Interleukin-10 (IL-10) is a key immune-suppressive cytokine produced by regulatory T-cells (Tregs) and by helper T-cells (TH). Here we review pleiotropic functions of IL-10 that impact the immune pathology of cancer. The role of IL-10 in cancer has become less certain with knowledge of its immune stimulatory functions. IL-10 is needed for T-helper cell functions, T-cell immune surveillance, and suppression of cancer-associated inflammation. By promoting tumor specific immune surveillance and hindering pathogenic inflammation IL-10 is emerging as a key cytokine in the battle of the host against cancer. IL-10 functions at the cross roads of immune stimulation and immune suppression in cancer. Immunological mechanisms of action of IL-10 can be ultimately exploited to develop novel and effective cancer therapies.