Diet selection in immunologically manipulated mice
Diet selection in immunologically manipulated mice
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DOI：
10.1016/j.imbio.2007.08.001
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发表时间：
2008-01-01
期刊：
影响因子：
2.8
通讯作者：
Nobrega, Alberto
中科院分区：
文献类型：
--
作者：
Teixeira, Gerlinde;Paschoal, Patricia Olaya;Nobrega, Alberto
饮食选择是野生动物每天必须处理的复杂问题。在它们的自然环境中，这些动物遇到了各种各样的食物，其中一些它们能够并准备吃，但并不是所有的都被吃掉了。除了生物因素外，我们将在本文中深入讨论其中一些因素，食物偏好的一个重要因素是社会接触。哺乳动物生理学的改变会对某些食物的选择或偏好产生深远的影响。另一方面，老年人味觉和嗅觉的下降，食物限制的程度，食物的感官特性（如外观，味道和气味）可以被认为是影响进食行为导致厌恶的因素。许多物种，包括人类，学会了将恶心与味觉联系起来，因此避免了特定的摄入，这已被证明是持久的。条件性味觉厌恶是一种联想学习的形式，其中动物对先前与疾病配对的食物的味道表现出厌恶。我们的研究小组研究了野生动物中小鼠经常食用的食物的摄入模式，这些食物对人类有潜在的过敏性，以研究这些食物的免疫学后果，如口服耐受性和肠道炎症过程。我们选择了两种种子，花生（Arachis hypogea）和腰果（Anacardium oceanentale）作为我们的抗原来源，因为第一种被认为是最有效的食物过敏原之一，第二种在人类环境中似乎很少过敏。我们使用2-3月龄的雄性和雌性、正常、成年CBA/J、A/J、C57 BL/6和Ba 1b/c小鼠以及杂交（C57 B1/6 x Ba 1b/c）F1、（Ba 1b/c x C57 B1/6）F1）、（C57 B1/6 x DBA 2）F1小鼠。食物偏好似乎是应变具体。动物对确定的种子耐受，然后用其蛋白提取物免疫，并在自然条件下再次暴露于种子，改变了它们的进食模式。我们认为，饮食选择，一个多因素的事件，是受遗传因素，如MHC和动物的免疫状态。(C)2007年，Elsevier GmbH。All rights reserved.
Diet selection is a complex problem that animals in wildlife have to deal with daily. In their natural environment, these animals meet a great variety of foods some of which they are able and prepared to eat, yet, not all of it is eaten. In addition to the biological factors, some of which we shall discuss deeper in this paper, an important factor in food preference is social contact. Alterations in the physiology of mammals can have profound effects on the choice or preference for certain foods. On the other hand the decline of taste and smell perception in the elderly, the degree of food restriction, the sensorial properties of foods (such as presentation, taste, and smell) can be considered factors that influence feeding behavior leading to aversion. Many species, including man, learn to associate nausea with taste, and as a consequence avoid its specific intake, which has been shown to be persistent. Conditioned taste aversion is a form of associative learning in which animals display an aversion to the taste of a food that has previously been paired with illness. Our group has investigated the pattern of ingestion of foods that are frequently eaten by mice in wildlife and are potentially allergenic to humans in order to study the immunological consequences to these foods such as oral tolerance and inflammatory processes of the gut. We have chosen two seeds, peanuts (Arachis hypogea) and cashew nuts (Anacardium occidentale), as our source of antigens as the first is considered to be one of the most potent food allergens and for the second there seems to be very little allergy in the human setting. We used male and female, normal, adult CBA/J, A/J, C57BL/6 and Ba1b/c mice 2-3 months old and hybrid (C57B1/6 x Ba1b/c) F1, (Ba1b/c x C57B1/6) F1), (C57B1/6 x DBA2) F1 mice. Food preference appeared to be strain-specific. Animals tolerized to a determined seed, then immunized with its protein extract and re-exposed to the seed in natura alter their feeding pattern. We suggest that diet selection, a multi-factorial event, is influenced by genetic factors such as the MHC and the immunological status of the animal. (C) 2007 Elsevier GmbH. All rights reserved.